Osteogenesis Imperfecta (OI) is a genetic disorder that affects cellular synthesis of Type-I collagen fibrils and causes extreme bone fragility. This study reports the effects of OI mutations in Tropocollagen (TC) molecules on strength of model Tropocollagen-Hydroxyapatite biomaterials with two different mineral [hydroxyapatite (HAP)] distributions using three dimensional atomistic simulations. Results show that the effect of TC mutations on the strength of TC-HAP biomaterials is insignificant. Instead, change in mineral distribution showed significant impact on the overall strength of TC-HAP biomaterials. Study suggests that TC mutations manifest themselves by changing the mineral distribution during hydroxyapatite growth and nucleation period.
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11 January 2010
Research Article|
January 12 2010
Effect of osteogenesis imperfecta mutations in tropocollagen molecule on strength of biomimetic tropocollagen-hydroxyapatite nanocomposites
Devendra K. Dubey;
Devendra K. Dubey
Aeronautics and Astronautics,
Purdue University
, Indiana 47907, USA
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Vikas Tomar
Vikas Tomar
a)
Aeronautics and Astronautics,
Purdue University
, Indiana 47907, USA
Search for other works by this author on:
Devendra K. Dubey
Vikas Tomar
a)
Aeronautics and Astronautics,
Purdue University
, Indiana 47907, USA
a)
Author to whom correspondence should be addressed. Tel.: (765)-494-3006. FAX: (765) 494-0307. Electronic mail: [email protected].
Appl. Phys. Lett. 96, 023703 (2010)
Article history
Received:
September 22 2009
Accepted:
December 07 2009
Citation
Devendra K. Dubey, Vikas Tomar; Effect of osteogenesis imperfecta mutations in tropocollagen molecule on strength of biomimetic tropocollagen-hydroxyapatite nanocomposites. Appl. Phys. Lett. 11 January 2010; 96 (2): 023703. https://doi.org/10.1063/1.3279158
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