In this letter we experimentally demonstrate the sensitivity and overall performance of iterative correction for light attenuation in optoacoustic tomography as a function of number of iterations and accuracy of the tissue optical properties estimations. Experimental optoacoustic data were obtained by circularly illuminating a tissue-mimicking phantom with a high intensity pulsed near infrared laser and measuring the subsequent acoustic waves using a broadband acoustic hydrophone. We showcase an improvement in image fidelity and quantification due to the iterative inversion but find the method sensitive to the background optical properties and of a diverging behavior when increasing the number of iterations.

1.
A.
Oraevsky
and
A.
Karabutov
, in
Biomedical Photonics Handbook
, edited by
T.
Vo-Dinh
(
CRC
,
Boca Raton
,
2003
) Chap. 34.
2.
L.
Wang
and
L. V.
Wang
, in
Photoacoustic Imaging and Spectroscopy
, edited by
L. V.
Wang
(
CRC
,
Boca Raton
,
2009
).
3.
R. A.
Kruger
,
P.
Liu
,
Y.
Fang
, and
C. R.
Appledom
,
Med. Phys.
22
,
1605
(
1995
).
4.
D.
Razansky
,
C.
Vinegoni
, and
V.
Ntziachristos
,
Opt. Lett.
32
,
2891
(
2007
).
5.
B. T.
Cox
,
S. R.
Arridge
,
K. P.
Kostli
, and
P. C.
Beard
,
Appl. Opt.
45
,
1866
(
2006
).
6.
D.
Razansky
and
V.
Ntziachristos
,
Med. Phys.
34
,
4293
(
2007
).
7.
A.
Kienle
and
M. S.
Patterson
,
J. Opt. Soc. Am. A Opt. Image Sci. Vis
14
,
246
(
1997
).
8.
M.
Schweiger
,
S. R.
Arridge
,
M.
Hiraoka
, and
D. T.
Delpy
,
Med. Phys.
22
,
1779
(
1995
).
9.
W.
Bangerth
,
R.
Hartmann
,
G.
Kanschat
,
ACM Trans. Math. Softw.
33
,
24
(
2007
).
10.
M.
Xu
and
L. V.
Wang
,
Phys. Rev. E
71
,
016706
(
2005
).
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