Hydroxyapatite is known as a substrate for effective adhesion of various biological cells and bacteria as well implantable biomimetic material replacing defective bone tissues. It is found that low energy electron irradiation induces its strong surface potential variation and gives rise to pronounced wettability modification. The found electron-modulation method of the hydroxyapatite wettability enables both wettability switching and its microscopic patterning, which may be used for fabrication of spatially arrayed hydroxyapatite for biological cells immobilization, gene transfer, etc.
REFERENCES
1.
J.
Lahann
, S.
Mitragotri
, T.-N.
Tran
, H.
Kaido
, J.
Sundaram
, I. S.
Choi
, S.
Hoffer
, Gabor A.
Somorjai
, and R.
Langer
, Science
299
, 371
(2003
).2.
C. J.
Wilson
, R. E.
Clegg
, D. I.
Leavelsey
, and M. J.
Pearcy
, Tissue Eng.
11
, 1
(2005
).3.
4.
C. D.
McCaig
and M.
Zhao
, BioEssays
19
, 819
(1997
).5.
S.
Abbott
, J.
Ralston
, G.
Reynolds
, and R.
Hayes
, Langmuir
15
, 8923
(1999
).6.
K.
Ichimura
, S.-K.
Oh
, and M.
Nakagawa
, Science
288
, 1624
(2000
).7.
N. L.
Abbott
, C. B.
Gorman
, and G. M.
Whitesides
, Langmuir
11
, 16
(1995
).8.
M.
Byloos
, H.
Al-Maznai
, and M.
Morin
, J. Phys. Chem. B
105
, 5900
(2001
).9.
B. S.
Gallardo
, V. K.
Gupta
, F. D.
Eagerton
, L. I.
Jong
, V. S.
Craig
, R. R.
Shah
, and N. L.
Abbott
, Science
283
, 57
(1999
).10.
C. M.
Niemeyer
and C. A.
Mirkin
, Nanobiotechnology
(Wiley-VCH
, Weinheim
, 2004
).11.
12.
D. F.
Williams
, in Advances in Biomaterials
, edited by C.
de Putter
, G. L.
de Lange
, K.
de Groot
, and A. J. C.
Lee
(Elsevier
, Amsterdam
, 1988
), Vol. 8
.13.
W.
Clark
, L.
Bammann
, and R.
Gibbons
, Infect. Immun.
33
, 908
(1978
).14.
15.
16.
R. H.
Doremus
, J. Mater. Sci.
27
, 285
(1992
).17.
J. M.
Gomez-Vega
, E.
Saiz
, A. P.
Tomsia
, G. W.
Marshall
, and S. J.
Marshall
, Biomaterials
21
, 105
(2000
).18.
G.
Rosenman
and D.
Aronov
, J. Phys. D
(submitted).19.
20.
G.
Rosenman
, D.
Aronov
, and Yu.
Dekhtyar
, U.S. Provisional Patent Application 60/730,021 (26.10.2005).21.
A.
Karlov
and V.
Shakhov
, Russian Federation Patent 2156325 (2000
).22.
M.
Nonnenmacher
, M. P.
O’Boyle
, and H. K.
Wickramasinghe
, Appl. Phys. Lett.
58
, 2921
(1991
).23.
24.
U.
Hersel
, C.
Dahmen
, and H.
Kessler
, Biomaterials
24
, 4385
(2003
).25.
C. D.
McCaig
and M.
Zhao
, BioEssays
19
, 819
(1997
).26.
K. Y.
Nishimura
, R. R.
Isseroff
, and R.
Nuccitelli
, J. Cell. Sci.
109
, 199
(1996
).27.
W. J. J.
Welters
and L. G. J.
Fokkink
, Langmuir
14
, 1535
(1998
).28.
G.
Rosenman
, D.
Aronov
, L.
Oster
, J.
Haddad
, G.
Mezinskis
, I.
Pavlovska
, M.
Chaikina
, and A.
Karlov
, J. Lumin.
(in press).29.
E.
Suzuki
and Y.
Hayashi
, J. Appl. Phys.
53
, 8880
(1982
).30.
31.
© 2006 American Institute of Physics.
2006
American Institute of Physics
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