We present surface-enhanced Raman scattering (SERS) studies of DNA nucleosides using biologically benign agarose-stabilized gold nanoparticles (AAuNP). We compare the SERS activity of nucleosides with AAuNP to that of commercially obtained citrate-stabilized gold nanoparticles and find the SERS activity to be an order of magnitude higher with AAuNP. The higher SERS activity is explained in terms of the agarose matrix, which provides pathways for the gold nanoparticles to have distinct arrangements that result in stronger internal plasmon resonances.

1.
G. L.
Liu
and
L. P.
Lee
,
Appl. Phys. Lett.
87
,
074101
(
2005
).
2.
Y. W. C.
Cao
,
R.
Jin
, and
C. A.
Mirkin
,
Science
297
,
1536
(
2002
).
3.
K.
Kneipp
,
H.
Kneipp
,
I.
Itzkan
,
R. R.
Dasari
, and
M. S.
Feld
,
J. Phys.: Condens. Matter
14
,
R597
(
2002
).
4.
R. C.
Bailey
,
J.-M.
Nam
,
C. A.
Mirkin
, and
J. T.
Hupp
,
J. Am. Chem. Soc.
125
,
13541
(
2003
).
5.
A.
Otto
, in
Light scattering in solids IV: Electronic Scattering, Spin Effects, SERS and Morphic Effects
, edited by
M.
Cardona
and
G.
Güntherodt
(
Springer
,
Berlin
,
1984
).
6.
T. L.
Haslett
,
L.
Tay
, and
M.
Moskovits
,
J. Chem. Phys.
113
,
1641
(
2000
).
7.
K.
Kneipp
,
H.
Kneipp
,
I.
Itzkan
,
R. R.
Dasari
, and
M. S.
Feld
,
Chem. Rev. (Washington, D.C.)
99
,
2957
(
1999
).
8.
K.
Kneipp
,
W. Y.
Wang
,
H.
Kneipp
,
L. T.
Perlman
,
I.
Itzkan
,
R. R.
Dasari
, and
M. S.
Feld
,
Phys. Rev. Lett.
78
,
1667
(
1997
).
9.
R. C.
Maher
,
L. F.
Cohen
,
P.
Etchegoin
,
H. J. N.
Hartigan
,
R. J. C.
Brown
, and
J. T.
Milton
,
J. Chem. Phys.
120
,
11746
(
2004
).
10.
P.
Etchegoin
,
L. F.
Chen
,
H.
Hartigan
,
R. J. C.
Brown
,
M. J. T.
Milton
, and
J. C.
Gallop
,
J. Chem. Phys.
119
,
5281
(
2003
).
11.
M. I.
Stockman
,
V. M.
Shalaev
,
M.
Moskovits
,
R.
Botet
, and
T. F.
George
,
Phys. Rev. B
46
,
2821
(
1992
).
12.
K.
Raghuraman
,
K. K.
Katti
, and
K.
Katti
(unpublished).
14.
U.
Kreibig
and
M.
Vollmer
,
Optical Properties of Metal Clusters
(
Springer
,
Berlin
,
1995
).
15.
N. H.
Jang
,
Bull. Korean Chem. Soc.
23
,
1790
(
2002
).
16.
J.-Y.
Xiong
,
J.
Narayanan
,
X.-Y.
Liu
,
T. K.
Chong
,
S. B.
Chen
, and
T.-S.
Chung
,
J. Phys. Chem. B
109
,
5638
(
2005
).
You do not currently have access to this content.