Electrostatic interactions play an important role in nanofluidic channels when the channel size is comparable to the Debye screening length. Electrostatic fields have been used to control concentration and transport of ions in nanofluidic transistors. Here, we report a transistor-reservoir-transistor circuit that can be used to turn “on” or “off” protein transport using electrostatic fields with gate voltages of . Our results suggest that global electrostatic interactions of the protein were dominant over other interactions in the nanofluidic transistor. The fabrication technique also demonstrates the feasibility of nanofluidic integrated circuits for the manipulation of biomolecules in picoliter volumes.
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Research Article| March 24 2006
Field-effect control of protein transport in a nanofluidic transistor circuit
Rohit Karnik, Kenneth Castelino, Arun Majumdar; Field-effect control of protein transport in a nanofluidic transistor circuit. Appl. Phys. Lett. 20 March 2006; 88 (12): 123114. https://doi.org/10.1063/1.2186967
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