Electroacoustic imaging is an imaging modality used to detect electric field energy distribution during electroporation, offering valuable guidance for clinical procedures, particularly in deep tissues. Traditionally, single-element piezoelectric transducers or arrays have been employed for this purpose. However, these piezoelectric sensors are sensitive to electromagnetic interference and require physical contact with the sample through a coupling medium, raising concerns for both clinical and preclinical applications. To overcome these limitations, a multi-channel random quadrature ultrasonics system has been developed, enabling non-contact detection of electroacoustic signals. In this study, we demonstrated that this non-contact technique effectively detects electroacoustic signals, identifies electroporation regions, and reconstructs electric energy distribution, offering a promising approach for monitoring electroporation therapy.
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13 January 2025
Research Article|
January 17 2025
Non-contact electroacoustic tomography with optical interferometer for electroporation therapy monitoring
Yifei Xu
;
Yifei Xu
(Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing)
1
Department of Biomedical Engineering, University of California
, Irvine, California 92617, USA
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Yuchen Song
;
Yuchen Song
(Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing)
1
Department of Biomedical Engineering, University of California
, Irvine, California 92617, USA
2
Beckman Laser Institute & Medical Clinic, University of California, Irvine
, Irvine, California 92612, USA
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Leshan Sun
;
Leshan Sun
(Formal analysis, Visualization)
1
Department of Biomedical Engineering, University of California
, Irvine, California 92617, USA
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Zhongping Chen
;
Zhongping Chen
a)
(Conceptualization, Project administration, Supervision, Writing – review & editing)
1
Department of Biomedical Engineering, University of California
, Irvine, California 92617, USA
2
Beckman Laser Institute & Medical Clinic, University of California, Irvine
, Irvine, California 92612, USA
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Liangzhong Xiang
Liangzhong Xiang
a)
(Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing)
1
Department of Biomedical Engineering, University of California
, Irvine, California 92617, USA
2
Beckman Laser Institute & Medical Clinic, University of California, Irvine
, Irvine, California 92612, USA
3
Department of Radiological Sciences, University of California
, Irvine, California 92697, USA
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Appl. Phys. Lett. 126, 023704 (2025)
Article history
Received:
October 16 2024
Accepted:
January 04 2025
Citation
Yifei Xu, Yuchen Song, Leshan Sun, Zhongping Chen, Liangzhong Xiang; Non-contact electroacoustic tomography with optical interferometer for electroporation therapy monitoring. Appl. Phys. Lett. 13 January 2025; 126 (2): 023704. https://doi.org/10.1063/5.0244192
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