Vascular disease poses a significant threat to human health. Effective detection methods for quantifying noninvasive arterial wall stiffness enable the early identification of populations exhibiting arteriosclerosis tendencies, providing substantial value for vascular disease prevention and treatment. However, current methods for evaluating arterial stiffness rely on simple tangent stiffness, which is affected by blood pressure fluctuations. This study utilizes a collapse model to investigate arterial deformation and pulse wave propagation under transmural pressure with different arterial wall thicknesses and material properties. Based on the pressure–area relationship of collapsed blood vessels, the relationship between pulse wave velocity and initial bending stiffness at the collapsed state is derived. A method is, then, proposed to evaluate the arterial wall bending stiffness incorporating cuff and photoplethysmography technology for assessing arteriosclerosis. This method is verified through a collapse experiment with a rubber tube and employed in measuring the initial bending stiffness of a human radial artery in vivo. The implementation of this measurement method facilitates vascular stiffness measurements beyond the restriction of tangent modulus and blood pressure changes, offering a quantitative evaluation of arterial wall stiffness. The technique can, therefore, amplify the precision and dependability of preliminary arteriosclerosis lesion diagnostic procedures.
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18 December 2023
Research Article|
December 18 2023
A noninvasive measurement technique for the initial bending stiffness of an arterial wall
Yixing Zhang
;
Yixing Zhang
(Conceptualization, Data curation, Formal analysis, Methodology, Writing – original draft)
1
School of Mechanics and Aerospace Engineering, Southwest Jiaotong University
, Chengdu 610031, China
2
Applied Mechanics and Structure Safety Key Laboratory of Sichuan Province
, Chengdu 610031, China
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Jun Ai;
Jun Ai
(Formal analysis, Validation, Writing – review & editing)
3
Laboratory of Flexible Electronics Technology, Tsinghua University
, Beijing 100084, China
4
Institute of Flexible Electronics Technology of THU
, Zhejiang, Jiaxing 314000, China
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Mingxing Shi
;
Mingxing Shi
a)
(Conceptualization, Supervision, Writing – review & editing)
1
School of Mechanics and Aerospace Engineering, Southwest Jiaotong University
, Chengdu 610031, China
2
Applied Mechanics and Structure Safety Key Laboratory of Sichuan Province
, Chengdu 610031, China
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Yinji Ma
Yinji Ma
a)
(Conceptualization, Formal analysis, Funding acquisition, Writing – review & editing)
3
Laboratory of Flexible Electronics Technology, Tsinghua University
, Beijing 100084, China
5
AML, Department of Engineering Mechanics, Tsinghua University
, Beijing 100084, China
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Appl. Phys. Lett. 123, 253701 (2023)
Article history
Received:
October 09 2023
Accepted:
November 21 2023
Citation
Yixing Zhang, Jun Ai, Mingxing Shi, Yinji Ma; A noninvasive measurement technique for the initial bending stiffness of an arterial wall. Appl. Phys. Lett. 18 December 2023; 123 (25): 253701. https://doi.org/10.1063/5.0180437
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