A phase-sensitive microscopy technique is proposed and demonstrated that employs the momentum correlations inherent in spontaneous parametric downconversion. One photon from a correlated pair is focused onto a microscopic target while the other is measured in the Fourier plane. This provides knowledge of the position and angle of illumination for every photon striking the target, allowing full post-production control of the illumination angle used to form an image. The versatility of this approach is showcased with asymmetric illumination and differential phase contrast imaging without any beam blocks or moving parts.

1.
A. M.
Smith
, “
From sight to light
,” in
From Sight to Light
(
University of Chicago Press
,
2014
).
2.
H.
Defienne
,
B.
Ndagano
,
A.
Lyons
, and
D.
Faccio
, “
Polarization entanglement-enabled quantum holography
,”
Nat. Phys.
17
,
591
597
(
2021
).
3.
C. A.
Casacio
,
L. S.
Madsen
,
A.
Terrasson
,
M.
Waleed
,
K.
Barnscheidt
,
B.
Hage
,
M. A.
Taylor
, and
W. P.
Bowen
, “
Quantum-enhanced nonlinear microscopy
,”
Nature
594
,
201
206
(
2021
).
4.
M.
D'Angelo
,
M. V.
Chekhova
, and
Y.
Shih
, “
Two-photon diffraction and quantum lithography
,”
Phys. Rev. Lett.
87
,
013602
(
2001
).
5.
Y.
Israel
,
S.
Rosen
, and
Y.
Silberberg
, “
Supersensitive polarization microscopy using NOON states of light
,”
Phys. Rev. Lett.
112
,
103604
(
2014
).
6.
M.
D'Angelo
,
A.
Valencia
,
M. H.
Rubin
, and
Y.
Shih
, “
Resolution of quantum and classical ghost imaging
,”
Phys. Rev. A
72
,
013810
(
2005
).
7.
M. J.
Padgett
and
R. W.
Boyd
, “
An introduction to ghost imaging: Quantum and classical
,”
Philos. Trans. R. Soc., A
375
,
20160233
(
2017
).
8.
T.
Gregory
,
P.-A.
Moreau
,
E.
Toninelli
, and
M. J.
Padgett
, “
Imaging through noise with quantum illumination
,”
Sci. Adv.
6
,
eaay2652
(
2020
).
9.
G.
Brida
,
M.
Genovese
, and
I. R.
Berchera
, “
Experimental realization of sub-shot-noise quantum imaging
,”
Nat. Photonics
4
,
227
230
(
2010
).
10.
G. B.
Lemos
,
V.
Borish
,
G. D.
Cole
,
S.
Ramelow
,
R.
Lapkiewicz
, and
A.
Zeilinger
, “
Quantum imaging with undetected photons
,”
Nature
512
,
409
412
(
2014
).
11.
Y.
Zhang
,
D.
England
, and
B.
Sussman
, “
Snapshot hyperspectral imaging with quantum correlated photons
,” arXiv:2204.05984 (
2022
).
12.
M.
Genovese
, “
Real applications of quantum imaging
,”
J. Opt.
18
,
073002
(
2016
).
13.
Y.
Zhang
,
A.
Orth
,
D.
England
, and
B.
Sussman
, “
Ray tracing with quantum correlated photons to image a three-dimensional scene
,”
Phys. Rev. A
105
,
L011701
(
2022
).
14.
C.
Maurer
,
A.
Jesacher
,
S.
Bernet
, and
M.
Ritsch-Marte
, “
What spatial light modulators can do for optical microscopy
,”
Laser Photonics Rev.
5
,
81
101
(
2011
).
15.
Z.
Liu
,
L.
Tian
,
S.
Liu
, and
L.
Waller
, “
Real-time brightfield, darkfield, and phase contrast imaging in a light-emitting diode array microscope
,”
J. Biomed. Opt.
19
,
106002
(
2014
).
16.
L.
Tian
,
J.
Wang
, and
L.
Waller
, “
3D differential phase-contrast microscopy with computational illumination using an LED array
,”
Opt. Lett.
39
,
1326
1329
(
2014
).
17.
L.
Tian
and
L.
Waller
, “
Quantitative differential phase contrast imaging in an LED array microscope
,”
Opt. Express
23
,
11394
11403
(
2015
).
18.
D.
Lee
,
S.
Ryu
,
U.
Kim
,
D.
Jung
, and
C.
Joo
, “
Color-coded LED microscopy for multi-contrast and quantitative phase-gradient imaging
,”
Biomed. Opt. Express
6
,
4912
4922
(
2015
).
19.
D.
Jung
,
J.-H.
Choi
,
S.
Kim
,
S.
Ryu
,
W.
Lee
,
J.-S.
Lee
, and
C.
Joo
, “
Smartphone-based multi-contrast microscope using color-multiplexed illumination
,”
Sci. Rep.
7
,
7564
(
2017
).
20.
P.
Goedhart
,
M.
Khalilzada
,
R.
Bezemer
,
J.
Merza
, and
C.
Ince
, “
Sidestream dark field (SDF) imaging: A novel stroboscopic LED ring-based imaging modality for clinical assessment of the microcirculation
,”
Opt. Express
15
,
15101
15114
(
2007
).
21.
G.
Zheng
,
C.
Kolner
, and
C.
Yang
, “
Microscopy refocusing and dark-field imaging by using a simple LED array
,”
Opt. Lett.
36
,
3987
3989
(
2011
).
22.
R.
Horstmeyer
,
J.
Chung
,
X.
Ou
,
G.
Zheng
, and
C.
Yang
, “
Diffraction tomography with Fourier ptychography
,”
Optica
3
,
827
835
(
2016
).
23.
C.
Ma
,
Z.
Liu
,
L.
Tian
,
Q.
Dai
, and
L.
Waller
, “
Motion deblurring with temporally coded illumination in an LED array microscope
,”
Opt. Lett.
40
,
2281
2284
(
2015
).
24.
S. B.
Mehta
and
C. J.
Sheppard
, “
Quantitative phase-gradient imaging at high resolution with asymmetric illumination-based differential phase contrast
,”
Opt. Lett.
34
,
1924
1926
(
2009
).
25.
D.
Hamilton
and
C.
Sheppard
, “
Differential phase contrast in scanning optical microscopy
,”
J. Microsc.
133
,
27
39
(
1984
).
26.
R.
Yi
,
K. K.
Chu
, and
J.
Mertz
, “
Graded-field microscopy with white light
,”
Opt. Express
14
,
5191
5200
(
2006
).
27.
A.
Nomerotski
, “
Imaging and time stamping of photons with nanosecond resolution in Timepix based optical cameras
,”
Nucl. Instrum. Methods Phys. Res., Sect. A
937
,
26
30
(
2019
).
28.
C.
Ianzano
,
P.
Svihra
,
M.
Flament
,
A.
Hardy
,
G.
Cui
,
A.
Nomerotski
, and
E.
Figueroa
, “
Fast camera spatial characterization of photonic polarization entanglement
,”
Sci. Rep.
10
,
6181
(
2020
).
29.
Y.
Zhang
,
D.
England
,
A.
Nomerotski
,
P.
Svihra
,
S.
Ferrante
,
P.
Hockett
, and
B.
Sussman
, “
Multidimensional quantum-enhanced target detection via spectrotemporal-correlation measurements
,”
Phys. Rev. A
101
,
053808
(
2020
).
30.
V.
Vidyapin
,
Y.
Zhang
,
D.
England
, and
B.
Sussman
, “
Characterisation of a single photon event camera for quantum imaging
,” arXiv:2211.13788 (
2022
).
31.
D. G.
England
,
B.
Balaji
, and
B. J.
Sussman
, “
Quantum-enhanced standoff detection using correlated photon pairs
,”
Phys. Rev. A
99
,
023828
(
2019
).
32.
B.
Ndagano
,
H.
Defienne
,
D.
Branford
,
Y. D.
Shah
,
A.
Lyons
,
N.
Westerberg
,
E. M.
Gauger
, and
D.
Faccio
, “
Quantum microscopy based on Hong–Ou–Mandel interference
,”
Nat. Photonics
16
,
384
389
(
2022
).
33.
C.
Torre
,
A.
McMillan
,
J.
Monroy-Ruz
, and
J. C. F.
Matthews
, “
Sub-μm axial precision depth imaging with entangled two-colour Hong-Ou-Mandel microscopy
,” arXiv:2212.02990 (
2022
).
34.
K.
Morimoto
,
A.
Ardelean
,
M.-L.
Wu
,
A. C.
Ulku
,
I. M.
Antolovic
,
C.
Bruschini
, and
E.
Charbon
, “
Megapixel time-gated SPAD image sensor for 2D and 3D imaging applications
,”
Optica
7
,
346
354
(
2020
).
35.
See https://global.canon/en/news/2021/20211215.html for details on forthcoming megapixel SPAD sensor.
You do not currently have access to this content.