Ultrasound B-mode imaging has been employed to monitor single agents and collective swarms of microrobots in vitro and ex vivo in controlled experimental conditions. However, low contrast and spatial resolution still limit the effective employment of such a method in a medical microrobotic scenario. Doppler-based ultrasound appears as a promising tool for tracking microrobots in echogenic and dynamic environments as biological tissues. In this Letter, we demonstrate that microrobot displacements can be used as a special signature for their visualization within echogenic media, where B-mode fails. To this aim, we induced vibrations of a magnetic soft microrobot through alternated magnetic fields and used ultrasound phase analysis to derive microrobot features such as size and position over time. By exploiting vibrations, we were able to perform imaging and tracking of a low contrast microrobot both in tissue-mimicking phantom and in chicken breast. The axial resolution was 38 μm, which is four times smaller than the B-mode resolution with the employed equipment. We also performed real-time tracking of the microrobot's positions along linear trajectories with a linear velocity up to 1 mm/s. Overall, the reported results pave the way for the application of the proposed approach for the robust monitoring of medical microrobots in tissue.
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4 January 2021
Research Article|
January 06 2021
Real-time imaging and tracking of microrobots in tissues using ultrasound phase analysis
S. Pane
;
S. Pane
a)
1
The BioRobotics Institute, Scuola Superiore Sant'Anna
, Pisa 56025, Italy
2
Department of Excellence in Robotics & AI, Scuola Superiore Sant'Anna
, Pisa 56127, Italy
a)Author to whom correspondence should be addressed: [email protected]
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V. Iacovacci
;
V. Iacovacci
1
The BioRobotics Institute, Scuola Superiore Sant'Anna
, Pisa 56025, Italy
2
Department of Excellence in Robotics & AI, Scuola Superiore Sant'Anna
, Pisa 56127, Italy
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E. Sinibaldi
;
E. Sinibaldi
3
Center for Micro-BioRobotics, Istituto Italiano di Tecnologia
, Pontedera 56025, Italy
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A. Menciassi
A. Menciassi
1
The BioRobotics Institute, Scuola Superiore Sant'Anna
, Pisa 56025, Italy
2
Department of Excellence in Robotics & AI, Scuola Superiore Sant'Anna
, Pisa 56127, Italy
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a)Author to whom correspondence should be addressed: [email protected]
Appl. Phys. Lett. 118, 014102 (2021)
Article history
Received:
October 12 2020
Accepted:
December 17 2020
Citation
S. Pane, V. Iacovacci, E. Sinibaldi, A. Menciassi; Real-time imaging and tracking of microrobots in tissues using ultrasound phase analysis. Appl. Phys. Lett. 4 January 2021; 118 (1): 014102. https://doi.org/10.1063/5.0032969
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