Focused ultrasound (FUS) is an established technique for non-invasive surgery and has recently attracted considerable attention as a potential method for non-invasive neuromodulation. While the pressure waves in FUS procedures have been extensively studied in this context, the accompanying shear waves are often neglected due to the relatively high shear compliance of soft tissues. However, in bony structures such as the skull, acoustic pressure can also induce significant shear waves that could propagate outside the ultrasound focus. Here, we investigate wave propagation in the human cranium by means of a finite-element model that accounts for the anatomy, elasticity, and viscoelasticity of the skull and brain. We show that, when a region on the scalp is subjected to FUS, the skull acts as a waveguide for shear waves that propagate with a speed close to 1500 m/s, reaching off-target structures such as the cochlea. In particular, when a sharp onset of FUS is introduced in a zone proximal to the intersection of the parietal and temporal cranium, the bone-propagated shear waves reach the inner ear in about 40 , leading to cumulative displacements of about 1 . We further quantify the effect of ramped and sharp application of FUS on the cumulative displacements in the inner ear. Our results help explain the off-target auditory responses observed during neuromodulation experiments and inform the development of mitigation and sham control strategies.
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Transcranial focused ultrasound generates skull-conducted shear waves: Computational model and implications for neuromodulation
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20 July 2020
Research Article|
July 24 2020
Transcranial focused ultrasound generates skull-conducted shear waves: Computational model and implications for neuromodulation
Hossein Salahshoor
;
Hossein Salahshoor
a)
1
Division of Engineering and Applied Science, California Institute of Technology
, Pasadena, California 91125, USA
a)Authors to whom correspondence should be addressed: [email protected], [email protected], and [email protected]
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Mikhail G. Shapiro
;
Mikhail G. Shapiro
a)
2
Division of Chemistry and Chemical Engineering, California Institute of Technology
, Pasadena, California 91125, USA
a)Authors to whom correspondence should be addressed: [email protected], [email protected], and [email protected]
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Michael Ortiz
Michael Ortiz
a)
1
Division of Engineering and Applied Science, California Institute of Technology
, Pasadena, California 91125, USA
a)Authors to whom correspondence should be addressed: [email protected], [email protected], and [email protected]
Search for other works by this author on:
Hossein Salahshoor
1,a)
Mikhail G. Shapiro
2,a)
Michael Ortiz
1,a)
1
Division of Engineering and Applied Science, California Institute of Technology
, Pasadena, California 91125, USA
2
Division of Chemistry and Chemical Engineering, California Institute of Technology
, Pasadena, California 91125, USA
a)Authors to whom correspondence should be addressed: [email protected], [email protected], and [email protected]
Appl. Phys. Lett. 117, 033702 (2020)
Article history
Received:
April 24 2020
Accepted:
June 22 2020
Citation
Hossein Salahshoor, Mikhail G. Shapiro, Michael Ortiz; Transcranial focused ultrasound generates skull-conducted shear waves: Computational model and implications for neuromodulation. Appl. Phys. Lett. 20 July 2020; 117 (3): 033702. https://doi.org/10.1063/5.0011837
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