Designing and implementing means of locally trapping magnetic beads and understanding the factors underlying the bead capture force are important steps toward advancing the capture-release process of magnetic particles for biological applications. In particular, capturing magnetically labeled cells using magnetic microstructures with perpendicular magnetic anisotropy (PMA) will enable an approach to cell manipulation for emerging lab-on-a-chip devices. Here, a Co (0.2 nm)/Ni (0.4 nm) multilayered structure was designed to exhibit strong PMA and large saturation magnetization (Ms). Finite element simulations were performed to assess the dependence of the capture force on the value of Ms. The simulated force profile indicated the largest force at the perimeter of the disks. Arrays of Co/Ni disk structures of (4–7) μm diameter were fabricated and tested in a microchannel with suspended fluorescent magnetic beads. The magnetic beads were captured and localized to the edge of the disks as predicted by the simulations. This approach has been demonstrated to enable uniform assembly of magnetic beads without external fields and may provide a pathway toward precise cell manipulation methods.
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19 August 2019
Research Article|
August 20 2019
Capturing magnetic bead-based arrays using perpendicular magnetic anisotropy
Yu-Ching Hsiao
;
Yu-Ching Hsiao
a)
1
Mechanical and Aerospace Engineering Department, University of California
, Los Angeles, Los Angeles, California 90095, USA
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Reem Khojah
;
Reem Khojah
a)
2
Bioengineering Department, University of California
, Los Angeles, California 90095, USA
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Xu Li;
Xu Li
1
Mechanical and Aerospace Engineering Department, University of California
, Los Angeles, Los Angeles, California 90095, USA
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Auni Kundu;
Auni Kundu
1
Mechanical and Aerospace Engineering Department, University of California
, Los Angeles, Los Angeles, California 90095, USA
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Cai Chen;
Cai Chen
1
Mechanical and Aerospace Engineering Department, University of California
, Los Angeles, Los Angeles, California 90095, USA
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Daniel B. Gopman;
Daniel B. Gopman
3
Materials Science and Engineering Division, National Institute of Standards and Technology
, Gaithersburg, Maryland 20899, USA
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Andres C. Chavez
;
Andres C. Chavez
1
Mechanical and Aerospace Engineering Department, University of California
, Los Angeles, Los Angeles, California 90095, USA
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Taehwan Lee
;
Taehwan Lee
4
Materials Science and Engineering Department, University of California
, Los Angeles, Los Angeles, California 90095, USA
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Zhuyun Xiao;
Zhuyun Xiao
5
Electrical and Computer Engineering Department, University of California
, Los Angeles, California 90095, USA
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Abdon E. Sepulveda
;
Abdon E. Sepulveda
1
Mechanical and Aerospace Engineering Department, University of California
, Los Angeles, Los Angeles, California 90095, USA
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Rob N. Candler;
Rob N. Candler
1
Mechanical and Aerospace Engineering Department, University of California
, Los Angeles, Los Angeles, California 90095, USA
5
Electrical and Computer Engineering Department, University of California
, Los Angeles, California 90095, USA
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Gregory P. Carman;
Gregory P. Carman
1
Mechanical and Aerospace Engineering Department, University of California
, Los Angeles, Los Angeles, California 90095, USA
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Dino Di Carlo;
Dino Di Carlo
1
Mechanical and Aerospace Engineering Department, University of California
, Los Angeles, Los Angeles, California 90095, USA
2
Bioengineering Department, University of California
, Los Angeles, California 90095, USA
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Christopher S. Lynch
Christopher S. Lynch
b)
1
Mechanical and Aerospace Engineering Department, University of California
, Los Angeles, Los Angeles, California 90095, USA
6
Bourns College of Engineering, University of California
, Riverside, California 92521, USA
b)Author to whom correspondence should be addressed: cslynch@engr.ucr.edu
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a)
Contributions: Yu.-C. Hsiao and R. Khojah contributed equally to this work.
b)Author to whom correspondence should be addressed: cslynch@engr.ucr.edu
Appl. Phys. Lett. 115, 082402 (2019)
Article history
Received:
December 14 2018
Accepted:
August 01 2019
Citation
Yu-Ching Hsiao, Reem Khojah, Xu Li, Auni Kundu, Cai Chen, Daniel B. Gopman, Andres C. Chavez, Taehwan Lee, Zhuyun Xiao, Abdon E. Sepulveda, Rob N. Candler, Gregory P. Carman, Dino Di Carlo, Christopher S. Lynch; Capturing magnetic bead-based arrays using perpendicular magnetic anisotropy. Appl. Phys. Lett. 19 August 2019; 115 (8): 082402. https://doi.org/10.1063/1.5085354
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