Efficient and controllable gene/drug delivery triggered by sonoporation is critical to cellular therapy. This study reports on repairable sonoporation for massive cells trapped on a phononic crystal plate (PCP). This mechanism is generated by the effects of enhanced near-boundary streaming around the manipulated cells. The streaming is achieved by significantly improving the tangential acoustic field gradient along the cell boundary through resonant PCP excitation of the nonleaky Lamb modes intrinsically existing in the uniform plate. This structured field-induced repairable sonoporation may constitute an effective tool for drug delivery and gene transfection.
Phononic crystal-enhanced near-boundary streaming for sonoporation
Fei Li, Fei Yan, Zhiyi Chen, Junjun Lei, Jinsui Yu, Mian Chen, Wei Zhou, Long Meng, Lili Niu, Junru Wu, Jiangyu Li, Feiyan Cai, Hairong Zheng; Phononic crystal-enhanced near-boundary streaming for sonoporation. Appl. Phys. Lett. 20 August 2018; 113 (8): 083701. https://doi.org/10.1063/1.5040415
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