We have developed a method of terahertz (THz) solid immersion (SI) microscopy for continuous-wave reflection-mode imaging of soft biological tissues with a sub-wavelength spatial resolution. In order to achieve strong reduction in the dimensions of the THz beam caustic, an electromagnetic wave is focused into the evanescent field volume behind a medium with a high refractive index. We have experimentally demonstrated a 0.15λ-resolution of the proposed imaging modality at λ = 500 μm, which is beyond the Abbe diffraction limit and represents a considerable improvement over the previously-reported arrangements of SI imaging setups. The proposed technique does not involve any sub-wavelength near-field probes and diaphragms, thus, avoiding the THz beam attenuation due to such elements. We have applied the developed method for THz imaging of various soft tissues: a plant leaf blade, cell spheroids, and tissues of the breast ex vivo. Our THz images clearly reveal sub-wavelength features in tissues, therefore, promising applications of THz SI microscopy in biology and medicine.
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10 September 2018
Research Article|
September 10 2018
Reflection-mode continuous-wave 0.15λ-resolution terahertz solid immersion microscopy of soft biological tissues
N. V. Chernomyrdin
;
N. V. Chernomyrdin
1
Prokhorov General Physics Institute of the Russian Academy of Sciences
, Moscow 119991, Russia
2
Sechenov First Moscow State Medical University
, Moscow 119991, Russia
3
Bauman Moscow State Technical University
, Moscow 105005, Russia
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A. S. Kucheryavenko;
A. S. Kucheryavenko
3
Bauman Moscow State Technical University
, Moscow 105005, Russia
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G. S. Kolontaeva;
G. S. Kolontaeva
3
Bauman Moscow State Technical University
, Moscow 105005, Russia
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G. M. Katyba;
G. M. Katyba
3
Bauman Moscow State Technical University
, Moscow 105005, Russia
4
Institute of Solid State Physics of the Russian Academy of Sciences
, Chernogolovka 142432, Russia
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I. N. Dolganova;
I. N. Dolganova
2
Sechenov First Moscow State Medical University
, Moscow 119991, Russia
3
Bauman Moscow State Technical University
, Moscow 105005, Russia
4
Institute of Solid State Physics of the Russian Academy of Sciences
, Chernogolovka 142432, Russia
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P. A. Karalkin;
P. A. Karalkin
5
3D Bioprinting Solutions
, Moscow 115409, Russia
6
National Medical Research Center of Radiology
, Moscow 125284, Russia
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D. S. Ponomarev;
D. S. Ponomarev
7
Institute of Ultra-High Frequency Semiconductor Electronics of the Russian Academy of Sciences
, Moscow 117105, Russia
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V. N. Kurlov
;
V. N. Kurlov
2
Sechenov First Moscow State Medical University
, Moscow 119991, Russia
4
Institute of Solid State Physics of the Russian Academy of Sciences
, Chernogolovka 142432, Russia
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I. V. Reshetov;
I. V. Reshetov
2
Sechenov First Moscow State Medical University
, Moscow 119991, Russia
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M. Skorobogatiy;
M. Skorobogatiy
8
Department of Engineering Physics, Polytechnique Montreal
, Montreal, Quebec H3T 1J4, Canada
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V. V. Tuchin
;
V. V. Tuchin
9
Saratov State University
, Saratov 410012, Russia
10
Tomsk State University
, Tomsk 634050, Russia
11
Institute of Precision Mechanics and Control of the Russian Academy of Sciences
, Saratov 410028, Russia
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K. I. Zaytsev
K. I. Zaytsev
a)
1
Prokhorov General Physics Institute of the Russian Academy of Sciences
, Moscow 119991, Russia
2
Sechenov First Moscow State Medical University
, Moscow 119991, Russia
3
Bauman Moscow State Technical University
, Moscow 105005, Russia
a)Author to whom correspondence should be addressed: kirzay@gmail.com
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a)Author to whom correspondence should be addressed: kirzay@gmail.com
Appl. Phys. Lett. 113, 111102 (2018)
Article history
Received:
June 20 2018
Accepted:
August 27 2018
Citation
N. V. Chernomyrdin, A. S. Kucheryavenko, G. S. Kolontaeva, G. M. Katyba, I. N. Dolganova, P. A. Karalkin, D. S. Ponomarev, V. N. Kurlov, I. V. Reshetov, M. Skorobogatiy, V. V. Tuchin, K. I. Zaytsev; Reflection-mode continuous-wave 0.15λ-resolution terahertz solid immersion microscopy of soft biological tissues. Appl. Phys. Lett. 10 September 2018; 113 (11): 111102. https://doi.org/10.1063/1.5045480
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