Various tumor types exhibit the spectral fingerprints in the absorption and reflection spectra in visible and especially in near- to short-wave-infrared wavelength ranges. For the purpose of spectral tumor diagnostics by means of diffuse reflectance spectroscopy, we developed a broadband light emitting diode (LED) source consisting of a blue LED for optical excitation, Lu3Al5O12:Ce3+,Cr3+ luminescent garnet for visible to near infrared emissions, and Bismuth doped GeO2 luminescent glass for near-infrared to short-wave infrared emissions. It emits broad-band light emissions continuously in 470–1600 nm with a spectral gap at 900–1000 nm. In comparison to the currently available broadband light sources like halogen lamps, high-pressure discharge lamps and super continuum lasers, the light sources of this paper has significant advantages for spectral tissue diagnostics in high-spectral stability, improved light coupling to optical fibers, potential in low light source cost and enabling battery-drive.

1.
I. J.
Bigio
and
S. G.
Brown
,
Cancer Biol. Ther.
3
(
3
),
259
(
2004
).
2.
B. J.
Tromberg
,
N.
Shah
,
R.
Lanning
,
A.
Cerussi
,
J.
Espinoza
,
T.
Pham
,
L.
Svaasand
, and
J.
Butler
,
Neoplasia
2
(
1–2
),
26
(
2000
).
3.
R.
Richards-Kortum
and
E.
Sevick-Muraca
,
Annu. Rev. Phys. Chem.
47
,
555
(
1996
).
4.
R. M. P.
Doornbos
,
R.
Lang
,
M. C.
Aalders
,
F. W.
Cross
, and
H. J. C. M.
Sterenborg
,
Phys. Med. Biol.
44
,
967
(
1999
).
5.
S.
Thomsen
and
D.
Tatman
,
Ann. N. Y. Acad. Sci.
838
,
171
(
1998
).
6.
D. J.
Evers
,
R.
Nachabé
,
D.
Hompes
,
F.
van Coevorden
,
G. W.
Lucassen
,
B. H. W.
Hendriks
,
M.-L. F.
van Velthuysen
,
J.
Wesseling
, and
T. J. M.
Ruers
,
Eur. J. Surg. Oncol.
39
(
1
),
68
(
2013
).
7.
J. W.
Spliethoff
,
W.
Prevoo
,
M. A.
Meier
,
J.
de Jong
,
H. M.
Klomp
,
D. J.
Evers
,
H. J.
Sterenborg
,
G. W.
Lucassen
,
B. H.
Hendriks
, and
T. J.
Ruers
,
Clin. Cancer Res.
22
(
2
),
357
(
2016
).
8.
L. L.
de Boer
,
B. G.
Molenkamp
,
T. M.
Bydlon
,
B. H.
Hendriks
,
J.
Wesseling
,
H. J.
Sterenborg
, and
T. J.
Ruers
,
Cancer Res. Treat.
152
(
3
),
509
(
2015
).
9.
G. C.
Langhout
,
J. W.
Spliethoff
,
S. J.
Schmitz
,
A. G.
Aalbers
,
M. F.
van Velthuysen
,
B. H.
Hendriks
,
T. J.
Ruers
, and
K. F.
Kuhlmann
,
Lasers Surg. Med.
47
,
559
(
2015
).
10.
T. M.
Bydlon
,
R.
Nachabé
,
N.
Ramanujam
,
H. J.
Sterenborg
, and
B. H.
Hendriks
,
J. Biophotonics
8
(
1–2
),
9
(
2015
).
11.
P. A.
Valdés
,
A.
Kim
,
F.
Leblond
,
O. M.
Conde
,
B. T.
Harris
,
K. D.
Paulsen
,
B. C.
Wilson
, and
D. W.
Roberts
,
J. Biomed. Opt.
16
(
11
),
116007
(
2011
).
12.
T.
Svensson
,
S.
Andersson-Engels
,
M.
Einarsdóttír
, and
K.
Svanberg
,
J. Biomed. Opt.
12
(
1
),
014022
(
2007
).
13.
W. C.
Lin
,
S. A.
Toms
,
M.
Johnson
,
E. D.
Jansen
, and
A.
Mahadevan-Jansen
,
Photochem. Photobiol.
73
(
4
),
396
(
2001
).
14.
V.
Sharma
,
E. O.
Olweny
,
P.
Kapur
,
J. A.
Cadeddu
,
C. G.
Roehrborn
, and
H.
Liu
,
Biomed. Opt. Express
5
(
5
),
1512
(
2014
).
15.
P.
Werahera
, “
Role of optical spectroscopy in diagnosis of prostate cancer
,” in
24th International Prostate Cancer
, Colorado (
2014
).
16.
R. M.
Schols
,
N. D.
Bouvy
,
F. P.
Wieringa
,
L.
Alic
, and
L. P. S.
Stassen
, “
Visible and infrared diffuse reflectance spectrometry during thyroid and parathyroid surgery
,” in
SAGES 2013 Annual Meeting of the Society of American Gastrointestinal and Endoscopic Surgeons Baltimore
(
2013
).
17.
J. W.
Spliethoff
, “
Spectral tissue sensing for guidance and monitoring in oncological procedures
,” Ph.D. thesis (
University of Twente
,
2015
), ISBN: 978-94-6259-902-4.
18.
D. J.
Evers
,
R.
Nachabé
,
H. M.
Klomp
,
J. W.
van Sandick
,
M. W.
Wouters
,
G. W.
Lucassen
,
B. H. W.
Hendriks
,
J.
Wesseling
, and
T. J. M.
Ruers
,
Clin. Lung Cancer
13
(
6
),
424
(
2012
).
19.
D. J.
Evers
,
R.
Nachabé
,
M.-J.
Vranken Peeters
,
J. A.
van der Hage
,
H. S.
Oldenburg
,
E. J.
Rutgers
,
G. W.
Lucassen
,
B. H. W.
Hendriks
,
J.
Wesseling
, and
T. J. M.
Ruers
,
Breast Cancer Res. Treat.
137
,
155
(
2013
).
20.
E.
Stoffels
,
I. E.
Kieft
,
R. E. J.
Sladek
,
L. J. M.
van den Bedem
,
E. P.
van der Laan
, and
M.
Steinbuch
,
Plasma Sources Sci. Technol.
15
,
S169
(
2006
).
21.
X.
Zhang
,
M.
Li
,
R.
Zhou
,
K.
Feng
, and
S.
Yang
,
Appl. Phys. Lett.
93
,
021502
(
2008
).
22.
S.
Iseki
,
K.
Nakamura
,
M.
Hayashi
,
H.
Tanaka
,
H.
Kondo
,
H.
Kajiyama
,
H.
Kano
,
F.
Kikkawa
, and
M.
Hori
,
Appl. Phys. Lett.
100
,
113702
(
2012
).
23.
L.
Solbiati
,
T.
Livraghi
,
S. N.
Goldberg
,
T.
Ierace
,
F.
Meloni
,
M.
Dellanoce
,
L.
Cova
,
E. F.
Halpern
, and
G. S.
Gazelle
,
Radiology
221
(
1
),
159
(
2001
).
24.
C.
Meyer
and
H.
Nienhuis
,
Discharge Lamps
(
Scholium International Inc
.,
New York
,
1988
), pp.
177
247
.
25.
W.
Wang
,
J.
Tang
,
S. T. V.
Hsu
,
J.
Wang
, and
B. P.
Sullivan
,
Chem. Phys. Lett.
457
(
1–3
),
103
(
2008
).
26.
L.
Wang
,
X.
Zhang
,
Z. D.
Hao
,
Y. S.
Luo
,
X. J.
Wang
, and
J. H.
Zhang
,
Opt. Express
18
(
24
),
25177
(
2010
).
27.
D.
Jia
,
L. A.
Lewis
, and
X.-J.
Wang
,
Electrochem. Solid-State Lett.
13
(
4
),
J32
(
2010
).
28.
E.
Raudonyte
,
H.
Bettentrup
,
D.
Uhlich
,
S.
Sakirzanovas
,
O.
Opuchovic
,
S.
Tautkus
, and
A.
Katelnikovas
,
Opt. Mater.
37
,
204
(
2014
).
29.
Y.
Fujimoto
and
M.
Nakatsuka
,
Jpn. J. Appl. Phys.
40
,
L279
(
2001
).
30.
H.-T.
Sun
,
J.
Zhou
, and
J.
Qui
,
Prog. Mater. Sci.
64
,
1
(
2014
).
31.
M. Y.
Sharonov
,
A. B.
Bykov
,
V.
Petricevic
, and
R. R.
Alfano
,
Opt. Lett.
33
(
18
),
2131
(
2008
).
32.
Q.
Qian
,
Q. Y.
Zhang
,
G. F.
Yang
,
Z. M.
Yang
, and
Z. H.
Jiang
,
J. Appl. Phys.
104
,
043518
(
2008
).
33.
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