The theoretical diffraction-limit of resolution for ultrasound imaging has recently been bypassed in-vitro and in-vivo. However, in the context of ultrasound therapy, the precision of therapeutic beams remains bound to the half-wavelength limit. By combining acoustic vaporization of composite droplets and rapid ultrasound monitoring, we demonstrate that the ultrasound drug-delivery can be restricted to a subwavelength zone. Moreover, two release zones closer than the wavelength/4 can be distinguished both optically and through ultrafast ultrasound localization microscopy. This proof-of-concept let us envision the possibility to treat specific tissues more precisely without compromising on the penetration depth of the ultrasound wave.
References
1.
G.
ter Haar
, Prog. Biophys. Mol. Biol.
93
(1
), 111
(2007
).2.
A.
Bouakaz
, A.
Zeghimi
, and A. A.
Doinikov
, “Sonoporation, concept and mechanisms
,” in Therapeutic Ultrasound
(Springer International Publishing
, 2016
), p.175
.3.
A.
Burgess
and K.
Hynynen
, “Microbubble-assisted ultrasound for drug delivery in the brain and central nervous system
,” in Therapeutic Ultrasound
(Springer International Publishing
, 2016
), p. 293
.4.
O.
Couture
, J.
Foley
, N. F.
Kassel
, B.
Larrat
, and J.-F.
Aubry
, Transl. Cancer Res.
3
(5
), 494
(2014
).5.
O.
Couture
, B.
Besson
, G.
Montaldo
, M.
Fink
, and M.
Tanter
, “Microbubble ultrasound super-localization imaging (MUSLI)
,” in IEEE Ultrasonics Symposium
(2011
), p. 1285
–1287
.6.
C.
Errico
, J.
Pierre
, S.
Pezet
, Y.
Desailly
, Z.
Lenkei
, O.
Couture
, and M.
Tanter
, Nature
527
(7579
), 499
(2015
).7.
E.
Betzig
, G. H.
Patterson
, R.
Sougrat
, O. W.
Lindwasser
, S.
Olenych
, J. S.
Bonifacino
, M. W.
Davidson
, L.-J.
Schwartz
, and H. F.
Hess
, Science
313
(5793
), 1642
(2006
).8.
O.
Couture
, M.
Faivre
, N.
Pannacci
, A.
Babataheri
, V.
Servois
, P.
Tabeling
, and M.
Tanter
, Med. Phys.
38
(2
), 1116
(2011
).9.
O.
Couture
, A.
Urban
, A.
Bretagne
, L.
Martinez
, M.
Tanter
, and P.
Tabeling
, Med. Phys.
39
(8
), 5229
(2012
).10.
O. D.
Kripfgans
, J. B.
Fowlkes
, D. L.
Miller
, O. P.
Eldevik
, and P. L.
Carson
, Ultrasound Med. Biol.
26
(7
), 1177
(2000
).11.
C.
Cohen
, R.
Giles
, V.
Sergeyeva
, N.
Mittal
, P.
Tabeling
, D.
Zerrouki
, J.
Baudry
, J.
Bibette
, and N.
Bremond
, Microfluid. Nanofluid.
17
, 959
–966
(2014
).12.
J. A.
Jensen
and N. B.
Svendsen
, IEEE Trans. Ultrason., Ferroelectr., Freq. Control
39
(2
), 262
(1992
).13.
M. G.
Gustafsson
, Proc. Natl. Acad. Sci. U. S. A.
102
(37
), 13081
(2005
).14.
W. W.
Roberts
, T. L.
Hall
, K.
Ives
, J. S.
Wolf
, J. B.
Fowlkes
, and C. A.
Cain
, J. Urol.
175
(2
), 734
(2006
).15.
M.
Emmer
, A.
Van Wamel
, D. E.
Goertz
, and N.
De Jong
, Ultrasound Med. Biol.
33
(6
), 941
–949
(2007
).16.
K. I.
Kawabata
, A.
Yoshizawa
, R.
Asami
, T.
Azuma
, H.
Yoshikawa
, H.
Watanabe
, K.
Sasaki
, K.
Hirata
, and S. I.
Umemura
, in IEEE Ultrasonics Symposium
(2006
), p. 517
.17.
P. S.
Sheeran
, S. H.
Luois
, L. B.
Mullin
, T. O.
Matsunaga
, and P. A.
Dayton
, Biomaterials
33
(11
), 3262
(2012
).18.
M.
Tanter
and M.
Fink
, IEEE Trans. Ultrason., Ferroelectr., Freq. Control
61
(1
), 102
(2014
).© 2016 Author(s).
2016
Author(s)
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