An immunosensor is proposed based on the indium-gallium-zinc-oxide (IGZO) electric-double-layer thin-film transistor (EDL TFT) with a separating extended gate. The IGZO EDL TFT has a field-effect mobility of 24.5 cm2 V−1 s−1 and an operation voltage less than 1.5 V. The sensors exhibit the linear current response to label-free target immune molecule in the concentrations ranging from 1.6 to 368 × 10−15 g/ml with a detection limit of 1.6 × 10−15 g/ml (0.01 fM) under an ultralow operation voltage of 0.5 V. The IGZO TFT component demonstrates a consecutive assay stability and recyclability due to the unique structure with the separating extended gate. With the excellent electrical properties and the potential for plug-in-card-type multifunctional sensing, extended-gate-type IGZO EDL TFTs can be promising candidates for the development of a label-free biosensor for public health applications.
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24 October 2016
Research Article|
October 24 2016
Extended-gate-type IGZO electric-double-layer TFT immunosensor with high sensitivity and low operation voltage Available to Purchase
Lingyan Liang
;
Lingyan Liang
a)
1Key Laboratory of Additive Manufacturing Materials of Zhejiang Province and Ningbo Institute of Material Technology and Engineering,
Chinese Academy of Sciences
, Ningbo 315201, People's Republic of China
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Shengnan Zhang;
Shengnan Zhang
1Key Laboratory of Additive Manufacturing Materials of Zhejiang Province and Ningbo Institute of Material Technology and Engineering,
Chinese Academy of Sciences
, Ningbo 315201, People's Republic of China
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Weihua Wu;
Weihua Wu
1Key Laboratory of Additive Manufacturing Materials of Zhejiang Province and Ningbo Institute of Material Technology and Engineering,
Chinese Academy of Sciences
, Ningbo 315201, People's Republic of China
2Institute of Materials Science, School of Materials Science and Engineering,
Shanghai University
, Shanghai 200072, China
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Liqiang Zhu;
Liqiang Zhu
1Key Laboratory of Additive Manufacturing Materials of Zhejiang Province and Ningbo Institute of Material Technology and Engineering,
Chinese Academy of Sciences
, Ningbo 315201, People's Republic of China
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Hui Xiao;
Hui Xiao
1Key Laboratory of Additive Manufacturing Materials of Zhejiang Province and Ningbo Institute of Material Technology and Engineering,
Chinese Academy of Sciences
, Ningbo 315201, People's Republic of China
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Yanghui Liu;
Yanghui Liu
1Key Laboratory of Additive Manufacturing Materials of Zhejiang Province and Ningbo Institute of Material Technology and Engineering,
Chinese Academy of Sciences
, Ningbo 315201, People's Republic of China
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Hongliang Zhang;
Hongliang Zhang
1Key Laboratory of Additive Manufacturing Materials of Zhejiang Province and Ningbo Institute of Material Technology and Engineering,
Chinese Academy of Sciences
, Ningbo 315201, People's Republic of China
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Kashif Javaid;
Kashif Javaid
1Key Laboratory of Additive Manufacturing Materials of Zhejiang Province and Ningbo Institute of Material Technology and Engineering,
Chinese Academy of Sciences
, Ningbo 315201, People's Republic of China
3Department of Physics,
Government College University Faisalabad
, Allama Iqbal Road, 38000 Faisalabad, Pakistan
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Hongtao Cao
Hongtao Cao
a)
1Key Laboratory of Additive Manufacturing Materials of Zhejiang Province and Ningbo Institute of Material Technology and Engineering,
Chinese Academy of Sciences
, Ningbo 315201, People's Republic of China
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Lingyan Liang
1,a)
Shengnan Zhang
1
Weihua Wu
1,2
Liqiang Zhu
1
Hui Xiao
1
Yanghui Liu
1
Hongliang Zhang
1
Kashif Javaid
1,3
Hongtao Cao
1,a)
1Key Laboratory of Additive Manufacturing Materials of Zhejiang Province and Ningbo Institute of Material Technology and Engineering,
Chinese Academy of Sciences
, Ningbo 315201, People's Republic of China
2Institute of Materials Science, School of Materials Science and Engineering,
Shanghai University
, Shanghai 200072, China
3Department of Physics,
Government College University Faisalabad
, Allama Iqbal Road, 38000 Faisalabad, Pakistan
a)
Authors to whom correspondence should be addressed. Electronic addresses: [email protected] and [email protected]
Appl. Phys. Lett. 109, 173501 (2016)
Article history
Received:
August 18 2016
Accepted:
October 12 2016
Citation
Lingyan Liang, Shengnan Zhang, Weihua Wu, Liqiang Zhu, Hui Xiao, Yanghui Liu, Hongliang Zhang, Kashif Javaid, Hongtao Cao; Extended-gate-type IGZO electric-double-layer TFT immunosensor with high sensitivity and low operation voltage. Appl. Phys. Lett. 24 October 2016; 109 (17): 173501. https://doi.org/10.1063/1.4966221
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