Hyperviscosity syndrome is triggered by high blood viscosity in the human body. This syndrome can result in retinopathy, vertigo, coma, and other unanticipated complications. Serum viscosity is one of the important factors affecting whole blood viscosity, which is regarded as an indicator of general health. In this letter, we propose and demonstrate a Brownian relaxation-based mixing frequency method to test human serum viscosity. This method uses excitatory and detection coils and Brownian relaxation-dominated superparamagnetic nanoparticles, which are sensitive to variables of the liquid environment such as viscosity and temperature. We collect the harmonic signals produced by magnetic nanoparticles and estimate the viscosity of unknown solutions by comparison to the calibration curves. An in vitro human serum viscosity test is performed in less than 1.5 min.
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3 August 2015
Research Article|
August 05 2015
Superparamagnetic nanoparticle-based viscosity test
Kai Wu
;
Kai Wu
Department of Electrical Engineering,
University of Minnesota
, 200 Union Street SE, Minneapolis, Minnesota 55455, USA
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Jinming Liu;
Jinming Liu
Department of Electrical Engineering,
University of Minnesota
, 200 Union Street SE, Minneapolis, Minnesota 55455, USA
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Yi Wang;
Yi Wang
Department of Electrical Engineering,
University of Minnesota
, 200 Union Street SE, Minneapolis, Minnesota 55455, USA
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Clark Ye;
Clark Ye
Department of Electrical Engineering,
University of Minnesota
, 200 Union Street SE, Minneapolis, Minnesota 55455, USA
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Yinglong Feng;
Yinglong Feng
Department of Electrical Engineering,
University of Minnesota
, 200 Union Street SE, Minneapolis, Minnesota 55455, USA
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Jian-Ping Wang
Jian-Ping Wang
a)
Department of Electrical Engineering,
University of Minnesota
, 200 Union Street SE, Minneapolis, Minnesota 55455, USA
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,
,
,
,
,
Jinming Liu
Yi Wang
Clark Ye
Yinglong Feng
Jian-Ping Wang
a)
Department of Electrical Engineering,
University of Minnesota
, 200 Union Street SE, Minneapolis, Minnesota 55455, USA
a)
Author to whom correspondence should be addressed. Electronic mail: [email protected]
Appl. Phys. Lett. 107, 053701 (2015)
Article history
Received:
June 16 2015
Accepted:
July 24 2015
Citation
Kai Wu, Jinming Liu, Yi Wang, Clark Ye, Yinglong Feng, Jian-Ping Wang; Superparamagnetic nanoparticle-based viscosity test. Appl. Phys. Lett. 3 August 2015; 107 (5): 053701. https://doi.org/10.1063/1.4928057
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