Cryptosporidium parvum is a common intestinal parasitic protozoan that causes gastroenteritis in man and animals. It poses high risks to drinking water supply because of its ubiquitous distribution in water and their oocysts are resistant to harsh environment conditions. In this work, we demonstrated the use of large-size chemical vapor deposition (CVD) grown graphene films configured as field-effect device for rapid electrical detection of Cryptosporidium parvum oocysts (Cp. oocysts). The presence of Cp. oocysts causes the change in the transport characteristics of the antibody-functionalized graphene device, which can be measured in terms of the dependence of the drain current on the sweep of the gate voltage or the real-time drain current data under a constant gate voltage. The high sensor sensitivity of 25 oocysts per milliliter solution and good specificity were evaluated, indicating it a promising candidate for detecting waterborne pathogens in water quality control.
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10 February 2014
Research Article|
February 12 2014
Real-time, sensitive electrical detection of Cryptosporidium parvum oocysts based on chemical vapor deposition-grown graphene
Jen It Wong;
Jen It Wong
1
Jiangsu-Singapore Joint Research Center for Organic/Bio-Electronics & Information, Displays and Institute of Advanced Materials (IAM), Nanjing Tech University
, 30 South Puzhu Road, Nanjing 211816, China
2
Pillar of Engineering Product Development, Singapore University of Technology and Design
, Singapore
138682
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Lu Wang;
Lu Wang
3
Department of Chemistry and Chemical Biology, Harvard University
, Cambridge, Massachusetts 02138, USA
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Yumeng Shi;
Yumeng Shi
2
Pillar of Engineering Product Development, Singapore University of Technology and Design
, Singapore
138682
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Tomás Palacios;
Tomás Palacios
4
Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology
, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
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Jing Kong;
Jing Kong
4
Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology
, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
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Xiaochen Dong;
Xiaochen Dong
a)
1
Jiangsu-Singapore Joint Research Center for Organic/Bio-Electronics & Information, Displays and Institute of Advanced Materials (IAM), Nanjing Tech University
, 30 South Puzhu Road, Nanjing 211816, China
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Hui Ying Yang
Hui Ying Yang
b)
2
Pillar of Engineering Product Development, Singapore University of Technology and Design
, Singapore
138682
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a)
E-mail: [email protected]
b)
E-mail: [email protected]
Appl. Phys. Lett. 104, 063705 (2014)
Article history
Received:
December 13 2013
Accepted:
January 05 2014
Citation
Jen It Wong, Lu Wang, Yumeng Shi, Tomás Palacios, Jing Kong, Xiaochen Dong, Hui Ying Yang; Real-time, sensitive electrical detection of Cryptosporidium parvum oocysts based on chemical vapor deposition-grown graphene. Appl. Phys. Lett. 10 February 2014; 104 (6): 063705. https://doi.org/10.1063/1.4864154
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