We demonstrate a series of advantages of microsphere-assisted imaging over confocal and solid immersion lens microscopies including intrinsic flexibility, better resolution, higher magnification, and longer working distances. We discerned minimal feature sizes of ∼50-60 nm in nanoplasmonic arrays at the illumination wavelength λ = 405 nm. It is demonstrated that liquid-immersed, high-index (n ∼ 1.9-2.1) spheres provide a superior image quality compared to that obtained by spheres with the same index contrast in an air environment. We estimate that using transparent microspheres at deep UV wavelengths of ∼200 nm might make possible imaging of various nanostructures with extraordinary high ∼30 nm resolution.

1.
B.
Hecht
,
B.
Sick
,
U. P.
Wild
,
V.
Deckert
,
R.
Zenobi
,
O. J. F.
Martin
, and
D. W.
Pohl
,
J. Chem. Phys.
112
,
7761
(
2000
).
2.
E. T. F.
Rogers
,
J.
Lindberg
,
T.
Roy
,
S.
Savo
,
J. E.
Chad
,
M. R.
Dennis
, and
N. I.
Zheludev
,
Nat. Mater.
11
,
432
(
2012
).
3.
T. J.
Gould
,
S. T.
Hess
, and
J.
Bewersdorf
,
Annu. Rev. Biomed. Eng.
14
,
231
(
2012
).
4.
P.
Wang
,
M. N.
Slipchenko
,
J.
Mitchell
,
C.
Yang
,
E. O.
Potma
,
X.
Xu
, and
J.-X.
Cheng
,
Nat. Photonics
7
,
449
(
2013
).
5.
6.
I. I.
Smolyaninov
,
Y.-J.
Hung
, and
C. C.
Davis
,
Science
315
,
1699
(
2007
).
7.
M.
Minsky
, “
Microscopy apparatus
,” U.S. patent 3,013,467 (19 December
1961
);
C.
Cremer
and
T.
Cremer
,
Microsc. Acta
81
,
31
(
1978
);
[PubMed]
T.
Wilson
and
A. R.
Carlini
,
J. Microsc.
149
,
51
(
1988
).
8.
S. M.
Mansfield
and
G. S.
Kino
,
Appl. Phys. Lett.
57
,
2615
(
1990
);
B. D.
Terris
,
H. J.
Mamin
,
D.
Rugar
,
W. R.
Studenmund
, and
G. S.
Kino
,
Appl. Phys. Lett.
65
,
388
(
1994
);
Y.
Gambin
,
O.
Legrand
, and
S. R.
Quake
,
Appl. Phys. Lett.
88
,
174102
(
2006
).
9.
E.
Abbe
,
Arch. Mikrosk. Anat.
9
,
413
(
1873
).
10.
J. W.
Strutt
(Lord Rayleigh), Philos. Mag.
8
,
261
(
1879
).
11.
C. M.
Sparrow
,
Astrophys. J.
44
,
76
(
1916
).
12.
W. V.
Houston
,
Phys. Rev.
29
,
478
(
1927
).
13.
J. Y.
Lee
,
B. H.
Hong
,
W. Y.
Kim
,
S. K.
Min
,
Y.
Kim
,
M. V.
Jouravlev
,
R.
Bose
,
K. S.
Kim
,
I.-C.
Hwang
,
L. J.
Kaufman
,
C. W.
Wong
,
P.
Kim
, and
K. S.
Kim
,
Nature
460
,
498
(
2009
);
D. R.
Mason
,
M. V.
Jouravlev
, and
K. S.
Kim
,
Opt. Lett.
35
,
2007
(
2010
);
[PubMed]
M. S.
Kim
,
T.
Scharf
,
M. T.
Haq
,
W.
Nakagawa
, and
H. P.
Herzig
,
Opt. Lett.
36
,
3930
(
2011
).
[PubMed]
14.
Z.
Wang
,
W.
Guo
,
L.
Li
,
B.
Luk'yanchuk
,
A.
Khan
,
Z.
Liu
,
Z.
Chen
, and
M.
Hong
,
Nat. Commun.
2
,
218
(
2011
).
15.
X.
Hao
,
C.
Kuang
,
X.
Liu
,
H.
Zhang
, and
Y.
Li
,
Appl. Phys. Lett.
99
,
203102
(
2011
).
16.
V. N.
Astratov
and
A.
Darafsheh
, “
Methods and systems for super-resolution optical imaging using high-index of refraction microspheres and microcylinders
,” U.S. patent application 14/042,834 (7 June
2012
).
17.
A.
Darafsheh
,
M. A.
Fiddy
, and
V. N.
Astratov
, in
IEEE Proceedings of the 14th International Conference on Transparent Optical Networks–ICTON'12, Coventry, England, 2–5 July 2012
(
IEEE
,
2012
), Paper No. Tu.A6.5.
18.
A.
Darafsheh
,
G. F.
Walsh
,
L.
Dal Negro
, and
V. N.
Astratov
,
Appl. Phys. Lett.
101
,
141128
(
2012
).
19.
A.
Darafsheh
, “
Optical super-resolution and periodical focusing effects by dielectric miscrospheres
,” Ph.D. dissertation (
University of North Carolina at Charlotte
,
2013
).
20.
L.
Li
,
W.
Guo
,
Y
,
Yan
,
S.
Lee
, and
T.
Wang
,
Light: Sci. Appl.
2
,
e104
(
2013
).
21.
H.
Yang
,
N.
Moullan
,
J.
Auwerx
, and
M. A. M.
Gijs
, “
Super-resolution biological microscopy using virtual imaging by a microsphere nanoscope
,”
Small
(published online).
22.
H.
Guo
,
Y.
Han
,
X.
Weng
,
Y.
Zhao
,
G.
Sui
,
Y.
Wang
, and
S.
Zhuang
,
Opt. Express
21
,
2434
(
2013
).
23.
Z.
Chen
,
A.
Taflove
, and
V.
Backman
,
Opt. Express
12
,
1214
(
2004
);
[PubMed]
X.
Li
,
Z.
Chen
,
A.
Taflove
, and
V.
Backman
,
Opt. Express
13
,
526
(
2005
).
[PubMed]
24.
P.
Ferrand
,
J.
Wenger
,
A.
Devilez
,
M.
Pianta
,
B.
Stout
,
N.
Bonod
,
E.
Popov
, and
H.
Rigneault
,
Opt. Express
16
,
6930
(
2008
).
25.
C. J. R.
Sheppard
and
P.
Török
,
J. Opt. Soc. Am. A
20
,
2156
(
2003
);
S.
Guo
,
H.
Guo
, and
S.
Zhuang
,
Appl. Opt.
48
,
321
(
2009
).
[PubMed]
26.
A.
Darafsheh
,
N. I.
Limberopoulos
,
J. S.
Derov
,
D. E.
Walker
, Jr.
,
M.
Durska
,
D. N.
Krizhanovskii
,
D. M.
Whittaker
, and
V. N.
Astratov
,
Proc. SPIE
8594
,
85940C
(
2013
).
27.
A.
Heifetz
,
J. J.
Simpson
,
S.-C.
Kong
,
A.
Taflove
, and
V.
Backman
,
Opt. Express
15
,
17334
(
2007
).
28.
Y. E.
Geints
,
A. A.
Zemlyanov
, and
E. K.
Panina
,
Opt. Soc. Am. B
29
,
758
(
2012
).
29.
A.
Devilez
,
B.
Stout
,
N.
Bonod
, and
E.
Popov
,
Opt. Express
16
,
14200
(
2008
).
30.
X.
Hao
,
X.
Liu
,
C.
Kuang
,
Y.
Li
,
Y.
Ku
,
H.
Zhang
,
H.
Li
, and
L.
Tong
,
Appl. Phys. Lett.
102
,
013104
(
2013
).
31.
C. J.
Regan
,
R.
Rodriguez
,
S.
Gourshetty
,
L.
Grave de Peralta
, and
A. A.
Bernussi
,
Opt. Express
20
,
20827
(
2012
).
32.
C. J.
Regan
,
D.
Dominguez
,
L.
Grave de Peralta
, and
A. A.
Bernussi
,
J. Appl. Phys.
113
,
183105
(
2013
).
33.
Y.
Duan
,
G.
Barbastathis
, and
B.
Zhang
,
Opt. Lett.
38
,
2988
(
2013
).
You do not currently have access to this content.