Biosensors based on optofluidic micro-bottle resonators are demonstrated. A self-referenced sensing scheme, differential mode sensing, is proposed and used to substantially suppress environmental noises and reach an ultralow noise equal detection limit of 10 fg/ml (∼0.15 fM) for bovine serum albumin molecules. This sensing scheme has high compatibility with any other microcavity sensors to get lower biosensing limit.

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