This study extended our recently developed noncontact diffuse correlation spectroscopy flowmetry system into noncontact diffuse correlation tomography (ncDCT) for three-dimensional (3-D) flow imaging of deep tissue. A linear array of 15 photodetectors and two laser sources connected to a mobile lens-focusing system enabled automatic and noncontact scanning of flow in a region of interest. These boundary measurements were combined with a finite element framework for DCT image reconstruction implemented into an existing software package. This technique was tested in computer simulations and using a tissue-like phantom with anomaly flow contrast design. The cylindrical tube-shaped anomaly was clearly reconstructed in both simulation and phantom. Recovered and assigned flow contrast changes in anomaly were found to be highly correlated: regression slope = 1.00, R2 = 1.00, and p < 10−5 in simulation and regression slope ≥ 0.97, R2 ≥ 0.96, and p < 10−3 in phantom. These results exhibit promise of our ncDCT technique for 3-D imaging of deep tissue blood flow heterogeneities.
Three-dimensional flow contrast imaging of deep tissue using noncontact diffuse correlation tomography
Yu Lin, Chong Huang, Daniel Irwin, Lian He, Yu Shang, Guoqiang Yu; Three-dimensional flow contrast imaging of deep tissue using noncontact diffuse correlation tomography. Appl. Phys. Lett. 24 March 2014; 104 (12): 121103. https://doi.org/10.1063/1.4869469
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