We show the technical feasibility of coating and micro patterning boron-doped ultrananocrystalline diamond (UNCD®) on metal microwires and of applying them as microsensors for the detection of dopamine in vivo using fast-scan cyclic voltammetry. UNCD electrode surface consistently generated electrochemical signals with high signal-to-noise ratio of >800 using potassium ferrocyanide-ferricyanide redox couple. Parylene patterned UNCD microelectrodes were effectively applied to detect dopamine reliably in vitro using flow injection analysis with a detection limit of 27 nM and in the striatum of the anesthetized rat during electrical stimulation of dopamine neurons.

Topics
Doping, Microsensor, Electronic noise, Plasma processing, Crystallographic defects, Diamond, Cyclic voltammetry, Electrochemical impedance spectroscopy, Polymers, Microelectrode arrays
© 2013 AIP Publishing LLC.
2013
AIP Publishing LLC
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