We show the technical feasibility of coating and micro patterning boron-doped ultrananocrystalline diamond (UNCD®) on metal microwires and of applying them as microsensors for the detection of dopamine in vivo using fast-scan cyclic voltammetry. UNCD electrode surface consistently generated electrochemical signals with high signal-to-noise ratio of >800 using potassium ferrocyanide-ferricyanide redox couple. Parylene patterned UNCD microelectrodes were effectively applied to detect dopamine reliably in vitro using flow injection analysis with a detection limit of 27 nM and in the striatum of the anesthetized rat during electrical stimulation of dopamine neurons.
Characterization of ultrananocrystalline diamond microsensors for in vivo dopamine detection
Prabhu U. Arumugam, Hongjun Zeng, Shabnam Siddiqui, Dan P. Covey, John A. Carlisle, Paul A. Garris; Characterization of ultrananocrystalline diamond microsensors for in vivo dopamine detection. Appl. Phys. Lett. 24 June 2013; 102 (25): 253107. https://doi.org/10.1063/1.4811785
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