Antibacterial assay of series hydroxyxanthone that was a synthesis via cyclization of phenol derivatives and acid derivatives with Eaton Reagent has been investigated through Escherichia coli, Bacillus cereus, Staphylococcus aureus and Salmonella typhimurium by diffusion well method. The possess antibacterial activity against Methicillin-resistant Staphylococcus aureus (MRSA) has been reported by molecular docking. The result reveals that the 1,3,6-tryhydroxyxanthone were effective in inhibiting the growth of Escherichia coli, Bacillus cereus, Staphylococcus aureus and Salmonella typhimurium in the inhibition zone of 30, 30, 35, than 34 mm respectively with MIC at 10%. There was a binding interaction between 1,3,6-tryhydroxyxanthone and the amino acid residues such as His38, His35, Val177, Lys150 and Met41 into methicillin-resistant Staphylococcus aureus (MRSA) (2x3f.pdb).

1.
M. C.
Enright
,
D. A.
Robinson
,
G.
Randle
,
E. J.
Feil
,
H.
Grundmann
, and
B. G.
Spratt
,
PNAS
99
(
11
),
7687
7692
(
2002
)
2.
E.
Yuanita
,
H. D.
Pranowo
,
M.
Mustofa
,
R. T.
Swasono
,
J.
Syahri
, and
Jumina
,
Chem. J. Mold.
14
(
1
),
68
76
(
2019
)
3.
E.
Yuanita
,
H. D.
Pranowo
,
D.
Siswanta
,
R. T.
Swasono
,
M.
Mustofa
,
A. K.
Zulkarnain
,
J.
Syahri
, and
Jumina
,
Chem. Chem. Technol.
12
(
3
),
290
295
(
2018
).
4.
J.
Syahri
,
E.
Yuanita
,
B. A.
Nurohmah
,
M. H.
Wathon
,
R.
Syafri
,
R.
Armunanto
,
B.
Purwono
,
Orient. J. Chem
,
33
(
1
),
29
40
(
2017
).
5.
T.
Kodama
,
T.
Ito
,
D. F.
Dibwe
,
S. Y.
Woo
, and
H.
Morita
,
Bioorg. Med. Chem. Lett.
27
, (
2397
2400
(
2017
).
6.
C.
Auranwiwat
,
K.
Trisuwan
,
A.
Saiai
,
S. G.
Pyne
, and
T.
Ritthiwigrom
,
Fitoterapia
,
98
,
179
183
(
2014
).
7.
Y. X.
Tang
,
W. W.
Fu
,
Z. C.
Xi
,
J. L.
Yang
,
C. W.
Zheng
,
Y.
Lv
,
Z. W.
Shen
, and
H. X.
Xu
,
Phytochem. Lett.
1
(
4
),
211
214
(
2008
).
8.
J. J. Koh. S.
Lin
,
Y.
Bai
,
W.
Wan
,
L.
Sin
,
T. T.
Aung
,
J.
Li
,
V.
Chandra
, and
K.
Pervushin
Biochimica et Biophysica Acta (BBA) - Biomembranes
1860
(
1
),
2281
2298
(
2018
).
9.
L. F-B.
Fguira
,
S.
Fotso
,
R.
Ben Ameur-Mehdi
, et al,
Res. Microbiol.
156
,
341
347
(
2005
).
10.
K.
Konaté
,
J. F.
Mavoungou
,
A. N.
Lepengué
,
R. R.
Aworet-Samseny
,
A.
Hilou
,
A.
Souza
,
M. H.
Dicko
, and
B.
M’batchi
,
Ann. Clin. Microbiol. Antimicrob.
11
(
1
),
1
12
(
2012
).
11.
V.G.
De Billerbeck
,
Phytotherapie
5
,
249
253
(
2007
).
12.
K.
Das
,
R. K. S.
Tiwari
, and
D. K.
Shrivastava
,
J. Med. Plants Res.
4
104
111
(
2010
).
13.
N.G.
Heatley
,
Biochem. J.
38
,
61
65
(
1944
).
14.
C.
Perez
,
M.
Pauli
and
P.
Bazerque
,
Acta Biologiae et Medecine Experimentalis
15
,
113
115
(
1990
).
15.
National Committee for Clinical Laboratory Standards (NCCLS)
,
Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically -Approved Standards M7-A4,
CLSI
,
Wayne
,
1997
).
16.
C. K.
Lim
,
L. Y.
Tho
,
L. M.
Lim
,
S. A. A.
Shah
, and
J. F. F.
Weber
,
Lett. Org. Chem.
9
(
8
),
549
555
(
2012
).
This content is only available via PDF.