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Research Article| December 10 2019

DNA adducts, genotoxicity mechanism of alkyl compounds in association with forensic dentistry

Angger Waspodo Dias Adrianto;

Angger Waspodo Dias Adrianto

1

Department of Oral Biology The Division of Forensic Odontology, Faculty of Dentistry, Universitas Indonesia

, Jl. Salemba Raya No. 4, Central Jakarta 10430

Indonesia

3

Department of Biomedic, Faculty of Dentistry, University of Muhammadiyah Semarang

, Jl. Kedungmundu Raya No.18 Semarang, 50273

Indonesia

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Bambang Tri Hartomo;

Bambang Tri Hartomo

1

Department of Oral Biology The Division of Forensic Odontology, Faculty of Dentistry, Universitas Indonesia

, Jl. Salemba Raya No. 4, Central Jakarta 10430

Indonesia

2

Dental Medicine Program, Medical Faculty, Universitas Jenderal Soedirman

, Indonesia, Purwokerto, Central Java,

Indonesia

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Nurtami Soedarsono;

Nurtami Soedarsono

1

Department of Oral Biology The Division of Forensic Odontology, Faculty of Dentistry, Universitas Indonesia

, Jl. Salemba Raya No. 4, Central Jakarta 10430

Indonesia

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Elza Ibrahim Auerkari

Elza Ibrahim Auerkari ^a)

1

Department of Oral Biology The Division of Forensic Odontology, Faculty of Dentistry, Universitas Indonesia

, Jl. Salemba Raya No. 4, Central Jakarta 10430

Indonesia

^a)Corresponding author: [email protected]

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Author & Article Information

^a)Corresponding author: [email protected]

AIP Conf. Proc. 2193, 030002 (2019)

https://doi.org/10.1063/1.5139339

In addition to fingerprints and DNA analysis, forensic dentistry through dental records offers one of the main methods of forensic identification in challenging cases. Combining the methods of forensic dentistry and DNA analysis can further improve the chances of positive identification. Often the sampling of the victim is done in the area of the mouth, teeth, and periodontal tissue, then DNA testing is carried out. One test type aims to characterize the DNA damage (DNA adducts) induced by alkylating agent genotoxicity. The DNA adducts that can be observed are N⁷- methylguanine, O⁶-methylguanine, and O⁴-methylthymine. O⁶-methylguanine or O⁶-methylguanine methyltransferase (MGMT) as repair pathway can be a biomarker of oral squamous cell carcinoma. Therefore, the role of forensic dentistry to analyze oral cancer as one cause of a person’s death.

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© 2019 Author(s).

2019

Author(s)