Hydrocortisone is a corticosteroid drug used for topical atopic dermatitis treatment. Hydrocortisone has solubility on low water and also has low bioavailability. This is made in the system of nanoemulsion and nanoemulsion gel. The manufacture of hydrocortisone nanoemulsion used palm oil as an oil phase with various concentration from 10%, 12%, and 14%. This study aims to know the physicochemical characteristic and in vitro release of nanoemulsion and nanoemulsion gel. Nanoemulsion of hydrocortisone made with the emulsification method. The result shows that nanoemulsion and nanoemulsion gel of hydrocortisone with various oil phase concentration was suitable with the specified specs. The result of the particle size test of nanoemulsion formulation 1 (374 nm), 2 (395 nm), 3 (468 nm). Meanwhile, the result of the nanoemulsion gel was formulation 1 (447,8 nm), (543,2 nm), 3 (516,8 nm). Flux of nanoemulsion in vitro release test formulation 1, 2, 3 were 5,54 ± 0,24; 3,45 ± 0,43; and 3,08 ± 0,07. Whereas the gel nanoemulsion result were 2,96 ± 0,06; 2,61 ± 0,21; and 2,39 ± 0,32. The conclusion of this study is the optimal concentration of palm oil was 10% and a gel basis on nano-emulsion not affected the release of hydrocortisone.

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