Study on long-term toxicity of E-hong tablets to rats

To observe the effect of E-Hong tablet on long-term toxicity in rats, sixty rats were randomly divided into three groups, 20 rats in each group. According to the weight of the animals, the drug feed was given once every day, and the dosage was adjusted according to the change of body weight every week. The control group was only given no medicine feed and was fed continuously for 8 weeks, and the weight was weighed once a week, and the animal activity, hair and feces were observed. After treatment, 10 animals were taken from each group (the other animals continued to be kept for 2 weeks), blood samples were collected for routine examination, liver and kidney function, heart, liver, spleen, lung, kidney, stomach, thymus, adrenal gland, a total of 8 organs, fixed with 10% formaldehyde, covered with paraffin. E staining and histopathological examination. Results: the rats in the medication group and the control group had normal activities, active behavior, smooth hair, no abnormal and no death during the 8-week test period. There was no significant difference in blood routine, liver and kidney function test results. The appearance of viscera was normal and no special pathological changes were found in pathological anatomy and histopathology (P > 0.05). In conclusion, the toxicity of E-Hong tablet is very small, this experiment provides safe basis for clinical application.