This research is an attempt to get the lowest Energy Specific consumption from a combination of spray drying systems and refrigeration systems with double condensers. Drying is simulated in a low temperature range for heat sensitive materials. The thermodynamic simulation in this study was carried out to replace refrigerant R-134a with another refrigerant that meets the operational temperature of drying heat-sensitive materials. Refrigerant R-152a has the lowest specific energy consumption value compared to R-12, R-134a and R-600a refrigerants. Refrigerant R-152a is recommended to replace R-134a in using a spray drying system combination tool and refrigeration system with double condensers for heat sensitive materials with energy savings of more than 39%.

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