Engineering an active micropump module to integrate in a portable Polymerase Chain Reaction (PCR) is the ultimate goal of this study. This paper investigates the design of pneumatic pumping module to be embedded in a microfluidic system such as PCR kit. A simulation was introduced to verify the design of the pneumatic micropump module to serve the pumping action in the system. Ultimately, the testing showed that the realized micropump module confirmed the functionality of the pump without any leakage and backflow.
References
1.
V.
Pelt-Verkuil
, B.
Van
and J. P, “A Brief Comparison Between in Vivo DNA Replication and in Vitro PCR Amplification,” in Principles and Technical Aspects of PCR Amplification
, Rotterdam
, Springer Netherlands
, 2008
, pp. 9
–15
.2.
Whulanza
, Y
, Aditya
, R.
, Arvialido
, R.
, Utomo
, M.S
and Bachtiar
, B.M
“Ease Fabrication of PCR Modular Chip for Portable DNA Detection Kit
,” AIP Conference Prosiding
, vol. 1817
, p. 04006
, 2017
.3.
Phadke
, M.
, Shaner
, S.
, Shah
, S.
, Rodriguez
, Y.
, Wibowo
, D.
, Whulanza
, Y.
, Teriete
, P.
, Allen
, J.
and Kassegne
, S.
, 2018
. Inertial focusing and passive micro-mixing techniques for rare cells capturing microfluidic platform
. In ATP Conference Proceedings
(Vol. 1933
, No. 1
, p. 040001
). ATP Publishing.4.
Whulanza
, Y.
, Utomo
, M.S.
and Hilman
, A.
, 2018
. Realization of a passive micromixer using herringbone structure
. In ATP Conference Proceedings
(Vol. 1933
, No. 1
, p. 040003
). ATP Publishing.5.
M.
Gad-el-Hak
, “Journals of Fluid Engineering
,” The Fluid Mechanics of Microdevices
, pp. 5
–33
, 1999
.6.
P. S.
Dittrich
, K.
Tachikawa
and A.
Manz
, “Micro total analysis systems, latest advancement and trends,” in Analytical Chemistry
, Dortmund
, American Chemical Society
, 2006
, pp. 887
–908
.7.
B.
Pramanick
, P. K.
Dey
, S.
Das
and T. K.
Bhattacharyya
, “Design and Development of a PDMS Membrane based SU-8 Micropump for drug Delivery System
,” Journal of ISSS
, vol. 2
, no. 1
, pp. 1
–9
, 2013
.8.
C. H.
Chiou
, T. Y.
Yeh
and J. L.
Lin
, “Deformation analysis of a pneumatically-activated polydimethylsiloxane (PDMS) membrane and potential micro-pump applications
,” Micromachines
, vol. 6
, no. 2
, pp. 216
–229
, 2015
.9.
R.
Kant
, D.
Singh
and S.
Bhattacharya
, “Digitally controlled portable micropump for transport of live micro-organism
,” Sensors and Actuators A: Physical
, vol. 265
, pp. 138
–151
, 2017
.10.
L.-S.
Jang
, Y.-J.
Li
, S.-J.
Lin
, Y.-C.
Hsu
, W.-S.
Yao
, M.-C.
Tsai
and C.-C.
Hou
, “A stand-alone peristaltic micropump based on piezoelectric actuation
,” Biomedical microdevices
, vol. 9
, no. 2
, pp. 185
–194
, 2007
.11.
J. S.
Dong
, W. H.
Chen
, P.
Zeng
, R. G.
Liu
, C.
Shen
, W. S.
Liu
and B. S.
Lin
, “Design and experimental research on piezoelectric pump with triple vibrators
,” Microsystem Technologies
, vol. 23
, no. 8
, pp. 3019
–3026
, 2017
.12.
Y.
Yuan
, Y.
Yalikun
, N.
Ota
and Y.
Tanaka
, Property Tnvestigation of Replaceable PDMS Membrane as an Actuator in Microfluidic Device
, Multidisciplinary Digital Publishing Tnstitute
, 2018
.13.
B.
Pecar
, D.
Krizaj
, D.
Vrtacnik
, D.
Resnik
, T.
Dolzan
and M.
Mozek
, “Piezoelectric peristaltic micropump with a single actuator
,” Journal of Micromechanics and Microengineering
, vol. 24
, no. 10
, p. 105010
, 2014
.14.
G. T.
Bui
, J. H.
Wang
and J. L.
Lin
, “Optimization of Micropump Performance Utilizing a Single Membrane with an Active Check Valve
,” Micromachines
, vol. 9
, no. 1
, p. 1
, 2017
.15.
J.
Xiang
, Z.
Cai
, Y.
Zhang
and W.
Wang
, “A micro-cam actuated linear peristaltic pump for microfluidic applications
,” Sensors and Actuators A: Physical
, vol. 251
, pp. 20
–25
, 2016
.16.
D. J.
Laser
and J. G.
Santiago
, “A review of Micropumps
,” Journal of Micromechanics and Microengineering
, pp. 1
–30
, 2004
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2019
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