The gender difference on acute exacerbation of chronic obstructive pulmonary disease combined with osteoporosis

Background: with the gradually profound study on chronic obstructive pulmonary disease (COPD) in recent years, the clinical manifestation of COPD were found a great deal of heterogeneity. Simple “airflow obstructive level” did not fully reflect the heterogeneity, the increasingly attention were paid to the research on COPD clinical phenotype, especially the COPD gender difference. Chinese medicine put that gender and disease were correlation and differentiation, while, there was no correlation between gender differences and COPD traditional Chinese Medicine (TCM) syndromes in the literature. This study adopted the cross-sectional survey research method to summarize the gender distribution difference of TCM in AECOPD, in order to provide a new view for TCM prevention and diagnosis and treatment of COPD. Objective: to explore the characteristics of COPD in gender difference, and to summarize the differences in the distribution of common symptoms and syndromes in different gender. Method: A cross-sectional study was conducted to select AECOPD patients from The First Affiliated Hospital of Zhengzhou University from July 2014 to March 2016, and conducted epidemiological investigation and bone density examination. This study summarized the gender differences in epidemiology, clinical manifestations, test indexes, and complications of AECOPD patients; through syndrome investigation, this study analyzed the gender difference of TCM symptom and syndrome on AECOPD patients. Results: There were 289 cases in this study, including 183 cases of male, 106 cases of female, gender ratio was 1.73:1. Compared to male, it was more common on female with AECOPD combined with osteoporosis (P=0.0354). Conclusion: The results of this study showed that there were gender difference in TCM syndromes, age, complications, clinical symptoms and indicators of AECOPE patients. However, the samples quantity of this project was small and the selected patient’s scope was relatively limited. It may be insufficient in the distribution of different gender syndromes, which required further study. This paper discussed the distribution of different gender in AECOPD TCM syndrome and expected could provide new solutions for TCM prevention and diagnosis and treatment of COPD.