Objective: Through comparing and analyzing the clinical effect, adverse reaction rate, changes of postoperative hepatic function and blood routine examination polycinnamol and anhydrous alcohol in the treatment of hepatic cyst by percutaneous puncture sclerosing under the guidance of ultrasound, evaluate the advantages and disadvantages of two sclerosing agents in the treatment of simple hepatic cysts. Methods: Eighty-six patients with hepatic cyst collected from Department of Ultrasonic Puncture and Sclerosing Agent of Third Hospital of Jilin University during April, 2015 to April, 2017 were randomly divided into polycinnamol group and anhydrous alcohol group They will separately receive two kinds of sclerosing treatment under the guidance of ultrasound to compare the adverse reaction rate, the cure rate, the changes of TBil, ALT and AST before and after treatment, and the changes of blood routine 24 hours after operation. T test was used among the data groups, and the comparison between the count data groups was compared with the X2 test. Results: The concentration of blood ethanol in polycinnamol group was significantly lower than that in anhydrous alcohol group (P < 0.05). There was no significant difference between the two groups in the cure rate (1 month after operation and 6 months after operation), the changes of blood routine at 24 h after operation and the occurrence of adverse reactions (Average P > 0.05). There was no significant difference in ALT and AST between the poly-cinnamol group and the anhydrous alcohol group 1 week after operation. Conclusion: Ultrasound-guided polycinnamol and anhydrous ethanol sclerosing for simple hepatic cysts are safe, effective, less injured and have a higher clinical cure rate, but the adverse reactions caused by polycinnamol are less than those caused by anhydrous ethanol. The adverse effects on liver function were also lighter than that of anhydrous ethanol. The appropriate sclerosing agent should be selected in combination with the clinical data of the patients.

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