Objective To explore the occurrence of heroin use during Methadone Maintenance Treatment (MMT), analyze its related factors, and offer plausible plans for decreasing the rate of heroin use. Methods In 2018 June, professional investigators, using a closed questionnaire, conducted one-on-one surveys with 400 patients and collected information such as the general demographic characteristics, drug-use features, family relationships, etc. Binary Logistic Regression Analysis was employed to analyze the related factors of heroin use. Results The rate of heroin use in this research was 41.25% (165/400). Multivariate Logistic regression analysis showed that the factors related to the heroin using rate included unemployment (OR=2.298), residential solitude (OR=1.846), disharmonious family relationships (OR=4.010), and short treatment duration (OR=2.042). Conclusion in Guangdong, China, and the rate of heroin use was still high. The government should strengthen anti-drug education, arrange jobs for MMT patients, and corporate with patients’ families. Moreover, the MMT clinics should also elevate the quality in serving the patients.

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