This study aimed to prepare an anti-infective Eco-friendly dressing of chitin-lysozyme, which should have antibacterial activity in vitro and promote wound healing in vivo. The chitin-lysozyme was prepared using chitin (group Control) and dopamine gule (group A) methods respectively, at 2mg/ml, 4mg/ml, and 8mg /ml (Namely group B, C and D). Finally, the chitin-lysozyme was observed as lysozyme spherical particles and bedding dopamine colloid. FTIR showed that the lysozyme had been adhered and the contact angle test showed that the material was hydrophilic. In vitro antibacterial effect was significant and the role on E. coli was significantly weaker than that on S. aureus. The cytotoxicity of the chitin-lysozyme dressing was not found. On day 7, the healing rates were 35.2%, 37.9%, 56.4%, 71.9% and 75.1% in Group Control, A, B, C and D, respectively. The wound healing rate was higher in the C and D groups than these in the other three groups (P <0.05).
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2019
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