Single Garlic Oil (SGO) extract from Indonesian tropical plant contains active compound such as S-allyl-L-cysteine sulfoxides(alliin), allicin, Z-ajoene, and E-ajoene. SGO has been used for hyperlipidemia. This study observed the potency of SGO on body weight gain, liver weight, and improved hepatic steatosis that caused consumption of high-fat diet (HFD). Twenty-four males Balb C mice divided into six group: normal diet, HFD treated with statin 26 mg/kgBW (positive control), HFD without treatment (negative control), HFD treated with SGO 12.5 mg/kgBW, HFD treated with SGO 25 mg/kgBW, and HFD treated with 50 mg/kgBW. The result shown SGO treatment significantly decreased body weight gain and liver weight compared with negative control group (P < 0.05). SGO treatment also showed ameliorated hepatic steatosis and the hepatocyte has a similar shape with the normal group. This study shown that SGO has effective treatment on hyperlipidemia considered to suppress body weight gain, decreased liver and spleen weight, and improved hepatic steatosis.

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