Antioxidant role of taurine and oyster mushroom on kidneys of male mice induced by paraquat herbicide

The study aimed to explore potential antioxidant effects of organic taurine and oyster mushroom (Pleurotus ostreatus (Jacq.) P. Kumm) on diets of male mice induced by paraquat herbicide. Thirty male mice were assigned for this study. They were divided into five groups, namely control, oyster mushroom diet, paraquat, paraquat plus oyster mushroom diet, and paraquat plus taurine diet. The concentration of malondialdehyde (MDA), Glutathione, and superoxide dismutase (SOD) was measured, after three weeks animals were intraperitoneally given paraquat twice a week as much as 20 mg · kg⁻¹ BW. Taurine was given 15.6 g · kg⁻¹ BW and the oyster mushroom pellet was given 62.5 g · kg⁻¹ daily. Complete randomized design was applied to these groups and data was analyzed using ANOVA followed by LSD at 5 %. The results indicated that both additions of taurine and oyster mushroom on diets reduced the concentration of MDA for about 15 % and increased the glutathione concentration for about 30 % (p < 0.05), while the concentration of SOD did not show any significantly different among groups (p > 0.05), even though both taurine and oyster mushroom diets decreased SOD concentration for about 12 %. In conclusion, both taurine and oyster mushroom affected as an antioxidant by reducing the MDA concentration and increasing in glutathione concentration.