Increasing attention is being devoted to the interaction of a new class of organic ionic liquids known as room-temperature ionic liquids (RTILs) with biomolecules, partly because of health and environment concerns, and, even more, for the prospect of exciting new applications in biomedicine, sensing and energy technologies. Here we focus on the interaction between RTILs and phospholipid bilayers that are well-accepted models for bio-membranes. We discuss how neutron scattering has been used to probe both the structure and the dynamics of these systems, and how its integration with molecular dynamics simulation has allowed the determination of the microscopic details of their interaction.

1.
F. T.
Welton
,
Chem. Rev.
99
,
2071
(
1999
).
2.
N.V.
Plechkova
,
R.D.
Rogers
, and
K.R.
Seddon
, “Ionic Liquids: From Knowledge to Applications” in
ACS Symposium Series
(
American Chemical Society
,
Washington DC
,
2009
) p.
1030
.
3.
M.
Petkovic
,
K.R.
Seddon
,
L.P.N.
Rebelo
, and
C.S.
Pereira
,
Chemical Society Reviews
40
,
1383
(
2011
).
4.
W.L.
Hough
,
M.
Smiglak
,
H.
Rodriguez
,
R.P.
Swatloski
,
S.K.
Spear
,
D.Y.
Daly
,
J.
Pernak
,
J.E.
Grisel
,
R.D.
Carliss
,
M.D.
Soutullo
,
J.H.
Davis
, Jr.
, and
R.D.
Rogers
,
New J. Chem.
31
,
1429
(
2007
).
5.
J.
Stoimenovski
,
P.M.
Dean
,
E.I.
Izgorodina
, and
D.R.
MacFarlane
,
Faraday Discuss.
154
,
335
(
2012
).
6.
K.O.
Evans
,
J. Phys. Chem. B
112
,
8558
(
2008
).
7.
A.
Benedetto
,
R.J.
Bingham
, and
P.
Ballone
,
J. Chem. Phys.
142
,
124706
(
2015
).
8.
A.
Benedetto
, et al, in preparation. The paper will be available at: www.antoniobenedetto.eu
9.
A.
Benedetto
,
F.
Heinrich
,
M.A.
Gonzalez
,
G.
Fragneto
,
E.
Watkins
, and
P.
Ballone
,
J. Phys. Chem. B
118
,
12192
12206
(
2014
).
10.
K.
Fujita
,
D.R.
MacFarlane
, and
M.
Forsyth
,
Chem. Commun.
4804
(
2005
).
11.
R.
Vijayaraghavan
,
A.
Izgorodin
,
V.
Ganesh
,
M.
Surianarayanan
, and
D.R.
MacFarlane
,
Angew. Chem. Int. Ed.
49
,
1631
(
2010
).
12.
N.
Byrne
, and
C.A.
Angell
,
Chem. Communications
1046
(
2009
).
13.
H.R.
Kalhor
,
M.
Kamizi
,
J.
Akbari
, and
A.
Heydari
,
Biomacromolecules
10
,
2468
(
2009
).
14.
T.G.A.
Youngs
,
J.D.
Holbrey
,
C.L.
Mullan
,
S.E.
Norman
,
M.C.
Lagunas
,
C.
D’Agostino
,
M.D.
Mantle
,
L.F.
Gladden
,
D.T.
Bowron
, and
C.
Hardacre
,
Chem. Sci.
2
,
1594
(
2011
).
15.
A.
Benedetto
, and
P.
Ballone
,
ACS Sustainable Chem. Eng.
4
,
392
412
(
2016
).
16.
A.
Benedetto
, and
P.
Ballone
,
Phil. Mag.
96
,
870
894
(
2016
).
17.
F.
Volino
,
Spectroscopic Methods for the Study of Local Dynamics in Polyatomic Fluids
(
Plenum
,
New York
,
1978
).
18.
M.
Bee
,
Principles and Applications in Solid State Chemistry, Biology and Materials Science
(
Adam Hilger
,
1988
).
19.
S.
Magazu’
,
G.
Maisano
,
F.
Migliardo
, and
A.
Benedetto
,
J. Mol. Struct.
882
,
140
145
(
2008
).
20.
S.
Magazu’
,
G.
Maisano
,
F.
Migliardo
, and
A.
Benedetto
,
Biochim. Biophys. Acta
1804
,
49
55
(
2010
).
21.
M.L.
Berkowitz
, and
R.
Vaćha
,
Acc. Chem. Res.
45
,
74
82
(
2012
).
22.
R.A.
Böckmann
,
A.
Hac
,
T.
Heimburg
, and
H.
Grubmüller
,
Biophys. J.
85
,
1647
1655
(
2003
).
23.
G.
Pabst
,
A.
Hodzic
,
J.
Štrancar
,
S.
Danner
,
M.
Rappolt
, and
P.
Laggner
,
Biophys. J.
93
,
2688
2696
(
2007
).
24.
A.
Aroti
,
E.
Leontidis
,
M.
Dubois
, and
T.
Zemb
,
Biophys. J.
93
,
1580
1590
(
2007
).
25.
K.O.
Evans
,
Colloids Surf. A
274
,
11
17
(
2006
).
26.
K.O.
Evans
,
Int. J. Mol. Sci.
9
,
498
511
(
2008
).
27.
S.R.T.
Cromie
,
M.G.
Del Popolo
and
P.
Ballone
,
J. Phys. Chem. B
113
,
11642
(
2009
).
28.
R.J.
Bingham
and
P.
Ballone
,
J. Phys. Chem. B
116
,
11205
(
2012
).
29.
B.
Yoo
,
J.K.
Shah
,
Y.
Zhu
and
E.J.
Maginn
,
Soft Matter
10
,
8641
(
2014
).
30.
H.
Lee
and
T.-J.
Jeon
,
Phys. Chem. Chem. Phys.
17
,
5725
(
2015
).
31.
B.
Yoo
,
Y.
Zhu
and
E.J.
Maginn
,
Langmuir
32
,
5403
5411
(
2016
).
32.
B.
Yoo
, et al,
Sci. Rep.
6
,
19889
(
2016
).
33.
A.
Benedetto
,
E.
Bodo
,
L.
Gontrani
,
P.
Ballone
, and
R.
Caminiti
,
J. Phys. Chem. B
118
,
2471
2486
(
2014
).
34.
Kontro
I.
, et al,
Chem. Phys. Lipids
201
,
59
66
(
2016
)
35.
Jing
B.
, et al,
J. Phys. Chem. B
120
,
2781
2789
(
2016
)
This content is only available via PDF.