The term “metaplasticity” is a recent one, which means plasticity of synaptic plasticity. Correspondingly, neurometaplasticity simply means plasticity of neuroplasticity, indicating that a previous plastic event determines the current plasticity of neurons. Emerging studies suggest that neurometaplasticity underlie many neural activities and neurobehavioral disorders. In our previous work, we indicated that glucoallostasis is essential for the control of plasticity of the neural network that control error commission, detection and correction. Here we review recent works, which suggest that task precision depends on the modulatory effects of neuroplasticity on the neural networks of error commission, detection, and correction. Furthermore, we discuss neurometaplasticity and its role in error commission, detection, and correction.

1.
W. C.
Abraham
and
M. F.
Bear
,
Metaplasticity: the plasticity of synaptic plasticity
,
Trends Neurosci.
19
(
4
),
126
30
(
1996
).
2.
W. C.
Abraham
and
W. P.
Tate
,
Metaplasticity: a new vista across the field of synaptic plasticity
,
Prog Neurobiol.
52
(
4
),
303
23
(
1997
).
3.
M. O.
Welcome
,
N. E.
Mastorakis
and
V. A.
Pereverzev
,
Multilevel system coupling of error commission, detection and correction in the error monitoring and processing system are required for high precision task performance, and modulates neural plasticity through changes in glucoallostasis
,
Int. J. Med. Physiol.
2
,
27
34
(
2017
).
4.
M. O.
Welcome
,
N.
Mastorakis
,
V. A.
Pereverzev
and
E. V.
Pereverzeva
,
A model system of error commission, detection and correction for high precision error coupling in the error monitoring and processing system: role of glycemic allostasis regulation
.
Second Int. Conf. Math. Comp. Sci. Industry (IEEE, Conference Publishing Service, CPS
,
2015
), pp.
145
152
.
5.
F. Y.
Ismail
,
A.
Fatemi
and
M. V.
Johnston
,
Cerebral plasticity: Windows of opportunity in the developing brain
,
Eur. J. Paediatr. Neurol.
21
(
1
):
23
48
(
2017
).
6.
F.
Müller-Dahlhaus
and
U.
Ziemann
,
Metaplasticity in human cortex
.
Neuroscientists
21
(
2
),
185
202
(
2014
).
7.
T. V.
Bliss
and
A. R.
Gardner-Medwin
,
Long-lasting potentiation of synaptic transmission in the dentate area of the unanaestetized rabbit following stimulation of the perforant path
,
J. Physiol.
232
(
2
),
357
374
(
1973
).
8.
T. V.
Bliss
and
T.
Lomo
,
Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path
,
J. Physiol.
232
(
2
):
331
356
(
1973
).
9.
G. L.
Collingridge
,
S.
Peineau
,
J. G.
Howland
and
Y. T.
Wang
,
Long-term depression in the CNS
,
Nat. Rev. Neurosci.
11
,
459
473
(
2010
).
10.
M.
Ito
and
M.
Kano
,
Long-lasting depression of parallel fiber-Purkinje cell transmission induced by conjunctive stimulation of parallel fibers and climbing fibers in the cerebellar cortex
.
Neurosci Lett.
33
(
3
),
253
8
(
1982
).
11.
M.
Ito
,
M.
Sakurai
and
P.
Tongroach
,
Climbing fibre induced depression of both mossy fibre responsiveness and glutamate sensitivity of cerebellar Purkinje cells
,
J. Physiol.
324
,
113
134
(
1982
).
12.
G.
Barrionuevo
,
F.
Schottler
and
G.
Lynch
,
The effects of repetitive low frequency stimulation on control and “potentiated” synaptic responses in the hippocampus
,
Life Sci.
27
,
2385
(
1980
).
13.
Q.
Li
and
B. D.
Burrell
,
Associative, bidirectional changes in neural signaling utilizing NMDA receptor- and endocannabinoid-dependent mechanisms
,
Learn Mem.
18
(
9
),
545
53
(
2011
).
14.
J. R.
Sanes
and
J. W.
Lichtman
,
Can molecules explain long-term potentiation?
Nat. Neurosci.
2
,
597
604
(
1999
).
15.
R. C.
Malenka
and
M. F.
Bear
,
LTP and LTD: an embarrassment of riches
,
Neuron.
44
(
1
):
5
21
(
2004
).
16.
B. D.
Burrell
and
Q.
Li
,
Co-induction of long-term potentiation and long-term depression at a central synapse in the leech
,
Neurobiol Learn Mem.
90
(
1
),
275
279
(
2008
).
17.
G.
Kalantzis
and
H. Z.
Shouval
,
Structural plasticity can produce metaplasticity
,
PLoS One
4
(
11
),
e8062
(
2009
).
18.
M. P.
Mattson
,
Glutamate and neurotrophic factors in neuronal plasticity and disease
,
Ann. N. Y. Acad. Sci.
1144
,
97
112
(
2008
).
19.
T. V. P.
Bliss
,
S. F.
Cooke
,
Long-term potentiation and long-term depression: a clinical perspective
,
Clinics (Sao Paulo)
,
66
(Suppl
1
),
3
17
(
2011
).
20.
N.
Thirugnanasambandam
,
J.
Grundey
,
W.
Paulus
and
M. A.
Nitsche
,
Dose-dependent nonlinear effect of l-DOPA on paired associative stimulation-induced neuroplasticity in humans
,
J. Neurosci.
31
(
14
),
5294
5299
(
2011
).
21.
A.
Kazemi
,
M.
Rahmati
,
R.
Eslami
,
V.
Sheibani
,
Activation of neurotrophins in lumbar dorsal root probably contributes to neuropathic pain after spinal nerve ligation
,
Iran J. Basic. Med. Sci.
20
(
1
):
29
35
(
2017
).
22.
T.
Numakawa
,
N.
Yamamoto
,
S.
Chiba
,
M.
Richards
,
Y.
Ooshima
,
S.
Kishi
,
K.
Hashido
,
N.
Adachi
,
H.
Kunugi
,
Growth factors stimulate expression of neuronal and glial miR-132
,
Neurosci. Lett.
505
(
3
):
242
7
(
2011
).
23.
B.
Connor
,
M.
Dragunow
,
The role of neuronal growth factors in neurodegenerative disorders of the human brain
,
Brain Res. Brain Res. Rev.
27
(
1
):
1
39
(
1998
).
24.
D.
Giulian
,
B.
Johnson
,
J. F.
Krebs
,
M. J.
Tapscott
and
S.
Honda
,
A growth factor from neuronal cell lines stimulates myelin protein synthesis in mammalian brain
,
J. Neurosci.
11
(
2
):
327
36
(
1991
).
25.
G. J.
Siegel
,
B. W.
Agranoff
,
R. W.
Albers
,
S. K.
Fisher
,
M. D.
Uhler
, eds.,
Basic neurochemistry: molecular, cellular and medical aspects.
6th ed.
Philadelphia
:
Lippincott-Raven
,
1999
.
26.
Anita
Jaranowska
,
Federico
Bussolino
,
Valeria
Sogos
,
Marco
Arese
,
Giuliana M.
Lauro
,
Fulvia
Gremo
.
Platelet-activating factor production by human fetal microglia
,
Molecular and Chemical Neuropathology
,
24
:
95
(
1995
).
27.
H.-S.
Suh
,
M.-L.
Zhao
,
L.
Derico
,
N.
Choi
and
S. C.
Lee
,
Insulin-like growth factor 1 and 2 (IGF1, IGF2) expression in human microglia: differential regulation by inflammatory mediators
,
J. Neuroinflammation
10
:
805
(
2013
).
28.
M. F.
Kuo
,
W.
Paulus
,
M. A.
Nitsche
,
Boosting focally-induced brain plasticity by dopamine
,
Cereb. Cortex
,
18
(
3
),
648
51
(
2008
).
29.
T. E.
Foley
,
M.
Fleshner
,
Neuroplasticity of dopamine circuits after exercise: implications for central fatigue
,
NeuroMol. Med.
10
(
2
),
67
80
(
2008
).
30.
K.
Knaepen
,
M.
Goekint
,
E. M.
Heyman
,
R.
Meeusen
,
Neuroplasticity – exercise-induced response of peripheral brain-derived neurotrophic factor: a systematic review of experimental studies in human subjects
,
Sports Med.
40
(
9
),
765
801
(
2010
).
31.
R. J.
Davidson
and
B. S.
McEwen
,
Social influences on neuroplasticity: stress and interventions to promote well-being
,
Nat. Neurosci.
15
,
689
695
(
2012
).
32.
B. T.
Gillick
and
L.
Zirpel
,
Neuroplasticity: an appreciation from synapse to system
,
Arch. Phys. Med. Rehab.
93
(
10
),
1846
1855
(
2012
).
33.
C. A.
Simpkins
and
A. M.
Simpkins
, “
Neurons and neurotransmitters
”, in
Neuroscience for Clinicians
,
Springer
,
New York, NY
, (
2013
), pp.
77
91
.
34.
D. R.
Ireland
,
B.G.
Mockett
and
W.C.
Abraham
, Metaplasticity,
Encyclopedia of neuroscience
, edited by
L. R.
Squire
,
2009
, pp.
819
826
,.
35.
P.
Kehoe
and
W.
Shoemaker
,
Infant stress, neuroplasticity, and behavior
, in:
Developmental psychobiology. handbook of behavioral neurobiology
, vol.
13
, edited by
E. M.
Blass
,
Springer
,
Boston, MA
,
2001
, pp.
551
585
.
36.
J.-L.
Dreyer
,
New insights into the roles of microRNAs in drug addiction and neuroplasticity
,
Genome Med.
2
:
92
,
2010
.
37.
K. B.
Grey
,
B. D.
Burrell
,
Co-induction of LTP and LTD and its regulation by protein kinases and phosphatases
,
J. Neurophysiol.
103
(
5
),
2737
46
(
2010
).
38.
P. E.
Castillo
,
Presynaptic LTP and LTD of excitatory and inhibitory synapses
,
Cold Spring Harb. Biol.
4
(
2
):
a005728
(
2012
).
39.
K.
Ren
and
R.
Dubner
,
Pain facilitation and activity-dependent plasticity in pain modulatory circuitry: role of BDNF-TrkB signaling and NMDA receptors
,
Mol. Neurobiol.
35
(
3
),
224
35
(
2007
).
40.
B.
Moghaddam
and
H.
Homayoun
,
Divergent plasticity of prefrontal cortex networks
,
Neuropsychopharmacology
,
33
(
1
):
42
55
(
2008
).
41.
D.
Debanne
,
G.
Daoudal
,
V.
Sourdet
and
M.
Russier
,
Brain plasticity and ion channels
,
J. Physiol. Paris
,
97
(
4-6
),
403
14
(
2003
).
42.
M.-M.
Poo
,
M.
Pignatelli
,
T. J.
Ryan
,
S.
Tonegawa
,
T.
Bonhoeffer
,
K. C.
Martin
,
A.
Rudenko
,
L.-H.
Tsai
,
R. W.
Tsien
,
G.
Fishell
,
C.
Mullins
,
J. T.
Gonçalves
,
M.
Shtrahman
,
S. T.
Johnston
,
F. H.
Gage
,
Y.
Dan
,
J.
Long
,
G.
Buzsáki
and C Stevens,
What is memory? The present state of the engram
,
BMC Biol.
14
:
40
(
2016
).
43.
T. V. P.
Bliss
,
G. L.
Collingridge
,
B.-K.
Kaang
and
M.
Zhuo
,
Synaptic plasticity in the anterior cingulate cortex in acute and chronic pain
,
Nat. Rev. Neurosci.
17
,
485
496
(
2016
).
44.
Y.-F.
Lu
,
Y.
Wang
,
Y.
He
,
F.-K.
Zhang
,
T.
He
,
R.-R.
Wang
,
X.-F.
Chen
,
F.
Yang
,
K.-R.
Gong
and
J.
Chen
,
Spatial and temporal plasticity of synaptic organization in anterior cingulate cortex following peripheral inflammatory pain: multi-electrode array recordings in rats
,
Neurosci. Bull.
30
(
1
),
1
20
(
2014
).
45.
D. R.
Euston
,
A. J.
Gruber
and
B. L.
McNaughton
,
The role of medial prefrontal cortex in memory and decision making
.
Neuron
,
76
(
6
):
1057
1070
(
2012
).
46.
R.
Rong
,
B. L.
Meng
,
N.
Jiang
,
L. Q.
Hu
and
T. H.
Wang
,
Roles of BDNF in spinal neuroplasticity in cats subjected to partial dorsal ganglionectomy
,
Growth Factors
,
29
(
6
),
263
70
(
2011
).
47.
S.
Galer
,
M. O.
De Beeck
,
C.
Urbain
,
M.
Bourguignon
,
N.
Ligot
,
V.
Wens
,
B.
Marty
,
P.
Van Bogaert
,
P.
Peigneux
and
X.
De Tiège
,
Investigating the neural correlates of the Stroop effect with magnetoencephalography
,
Brain Topography
,
28
(
1
),
95
103
(
2015
).
48.
M.
Heldmann
,
J.
Rüsseler
and
T. F.
Münte
,
Internal and external information in error processing
,
BMC Neurosci.
9
:
33
(
2008
).
49.
B. C.
Castelluccio
,
S. A.
Meda
,
C. E.
Muska
,
M. C.
Stevens
and
G. D.
Pearlson
,
Error processing in current and former cocaine users
,
Brain Imaging Behav.
8
(
1
),
87
96
(
2014
).
50.
J. M.
Hyman
,
C. B.
Holroyd
and
J. K.
Seamans
,
A novel neural prediction error found in anterior cingulate cortex ensembles
,
Neuron
95
(
2
),
447
456.e3
(
2017
).
51.
A.
Navarro-Cebrian
,
R. T.
Knight
and
A. S.
Kayser
,
Error-monitoring and post-error compensations: dissociation between perceptual failures and motor errors with and without awareness
,
J. Neurosci.
33
(
30
)
12375
12383
(
2013
).
52.
A.
Toyomaki
,
N.
Hashimoto
,
Y.
Kako
,
H.
Murohashi
and
I.
Kusumi
,
Neural responses to feedback information produced by self-generated or other-generated decision-making and their impairment in schizophrenia
,
PLoS One
12
(
8
):
e0183792
(
2017
).
53.
K. A.
Page
,
D.
Seo
,
R.
Belfort-DeAguiar
,
C.
Lacadie
,
J.
Dzuira
,
S.
Naik
,
S.
Amarnath
,
R. T.
Constable
,
R. S.
Sherwin
and
R.
Sinha
,
Circulating glucose levels modulate neural control of desire for high-calorie foods in humans
,
J. Clin. Invest.
121
(
10
),
4161
9
(
2011
).
54.
K. A.
Page
,
O.
Chan
,
J.
Arora
,
R.
Belfort-Deaguiar
,
J.
Dzuira
,
B.
Roehmholdt
,
G. W.
Cline
,
S.
Naik
,
R.
Sinha
,
R. T.
Constable
,
R. S.
Sherwin
,
Effects of fructose vs glucose on regional cerebral blood flow in brain regions involved with appetite and reward pathways
,
JAMA
,
309
(
1
):
63
70
(
2013
).
55.
A.
Artola
,
Diabetes-, stress- and ageing-related changes in synaptic plasticity in hippocampus and neocortex - the same metaplastic process?
Eur. J. Pharmacol.
585
(
1
),
153
62
(
2008
).
56.
S. S.
Jeste
and
R.
Tuchman
,
Autism spectrum disorder and epilepsy: two sides of the same coin?
J. Child Neurol.
30
(
14
),
1963
1971
(
2015
).
57.
F. E.
Jensen
,
Epilepsy as a spectrum disorder: implications from novel clinical and basic neuroscience
,
Epilepsia
,
52
(
1
):
1
6
(
2011
).
58.
I.
Grande
,
G. R.
Fries
,
M.
Kunz
and
F.
Kapczinski
,
The Role of BDNF as a mediator of neuroplasticity in bipolar disorder
,
Psychiatry Investig.
7
(
4
),
243
250
(
2010
).
59.
A. D.
Falchook
,
K. M.
Heilman
,
G. R.
Finney
,
L. J.
Gonzalez-Rothi
and
S. E.
Nadeau
,
Neuroplasticity, neurotransmitters and new directions for treatment of anomia in Alzheimer disease
,
Aphasiology
28
(
2
),
219
235
(
2014
).
60.
M. A.
Nitsche
,
F.
Müller-Dahlhaus
,
W.
Paulus
and
U.
Ziemann
,
The pharmacology of neuroplasticity induced by non-invasive brain stimulation: building models for the clinical use of CNS active drugs
,
J. Physiol.
590
(
19
),
4641
62
(
2012
).
61.
B.
Czéh
and
M.
Simon
,
Neuroplasticity and depression
,
Psychiatr. Hung.
20
(
1
):
4
17
(
2005
).
62.
M. V.
Johnston
,
Clinical disorders of brain plasticity
,
Brain Dev.
26
(
2
),
73
80
(
2004
).
63.
F.
Kapczinski
,
B. N.
Frey
,
M.
Kauer-Sant’Anna
and
R.
Grassi-Oliveira
,
Brain-derived neurotrophic factor and neuroplasticity in bipolar disorder
,
Expert Rev. Neurother.
8
(
7
),
1101
13
(
2008
).
64.
J.
Nijs
,
M.
Meeus
,
J.
Versijpt
,
M.
Moens
,
I.
Bos
,
K.
Knaepen
and
R.
Meeusen
,
Brain-derived neurotrophic factor as a driving force behind neuroplasticity in neuropathic and central sensitization pain: a new therapeutic target?
Expert Opin. Ther. Targets
,
19
(
4
),
565
76
(
2015
).
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