This study was conducted as a pilot investigation on the protective influence of Carica papaya L. aqueous leaf extract (PLE) against experimental hyperuricemia and acute renal injury in an animal model. The effects of oral pre-treatment with PLE on BUA (blood uric acid) levels and renal histopathology of potassium bromate (KBrO3)-treated adult male albino mice were assessed. Sixty mice were randomized to six groups (n = 10): sham (sterile water) and KBrO3 controls; three experimental groups: PLE1, PLE2 and PLE3 (1, 2 and 3 g/kg body weight [BW] + KBrO3); and ascorbic acid (ascorbic acid 200 mg/kg BW + KBrO3) comparator. Oral pre-treatment with PLE was given for 14 d via gastric gavage. On day 14, except on the sham control, hyperuricemia was induced by oral administration of a single dose of KBrO3 200 mg/kg body weight. BUA levels were measured pre- and post-KBrO3 induction (at 333 h and 336 h, respectively). The kidneys were then immediately excised under anesthesia. Histopathologic evaluation of the kidneys was done using a standard numerical grading scheme. Results showed a significant increase in BUA levels in the KBrO3 control (p < 0.001). In the PLE groups, BUA levels were not significantly increased (p > 0.05). Histologically, there was significant attenuation of acute renal tissue damage in the PLE groups. However, the BUA and histopathologic responses of the PLE groups were not dose-dependent (p = 0.80 and p = 0.66, respectively). These preliminary findings suggest that PLE may have antihyperuricemic and nephroprotective effects in this murine model of hyperuricemia and acute renal tissue injury.
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14 June 2016
TOWARDS THE SUSTAINABLE USE OF BIODIVERSITY IN A CHANGING ENVIRONMENT: FROM BASIC TO APPLIED RESEARCH: Proceeding of the 4th International Conference on Biological Science
18–19 September 2015
Yogyakarta, Indonesia
Research Article|
June 14 2016
Protective influence of Carica papaya L. aqueous leaf extract against hyperuricemia and acute renal injury in a murine model
Pacifico Eric Calderon;
Pacifico Eric Calderon
a)
1College of Medicine,
San Beda College
, 638 Mendiola Street, San Miguel, 1005 Manila, Philippines
2Biology Department, College of Science,
De La Salle University
, 2401 Taft Avenue, 1004 Manila, Philippines
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Chrizarah San Juan;
Chrizarah San Juan
1College of Medicine,
San Beda College
, 638 Mendiola Street, San Miguel, 1005 Manila, Philippines
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Mary Grace San Pedro;
Mary Grace San Pedro
1College of Medicine,
San Beda College
, 638 Mendiola Street, San Miguel, 1005 Manila, Philippines
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Ariane Marie Reyes;
Ariane Marie Reyes
1College of Medicine,
San Beda College
, 638 Mendiola Street, San Miguel, 1005 Manila, Philippines
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Patrick Jerome Salom;
Patrick Jerome Salom
1College of Medicine,
San Beda College
, 638 Mendiola Street, San Miguel, 1005 Manila, Philippines
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Arnel Rheuim Sanchez;
Arnel Rheuim Sanchez
1College of Medicine,
San Beda College
, 638 Mendiola Street, San Miguel, 1005 Manila, Philippines
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Hazel Sandigan;
Hazel Sandigan
1College of Medicine,
San Beda College
, 638 Mendiola Street, San Miguel, 1005 Manila, Philippines
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Heshvey Joy Sangayab;
Heshvey Joy Sangayab
1College of Medicine,
San Beda College
, 638 Mendiola Street, San Miguel, 1005 Manila, Philippines
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Maria Cristine Joy Saure;
Maria Cristine Joy Saure
1College of Medicine,
San Beda College
, 638 Mendiola Street, San Miguel, 1005 Manila, Philippines
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Mar Henrick Savilla;
Mar Henrick Savilla
1College of Medicine,
San Beda College
, 638 Mendiola Street, San Miguel, 1005 Manila, Philippines
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Desmond Santos;
Desmond Santos
1College of Medicine,
San Beda College
, 638 Mendiola Street, San Miguel, 1005 Manila, Philippines
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Jamee Lou Santos;
Jamee Lou Santos
1College of Medicine,
San Beda College
, 638 Mendiola Street, San Miguel, 1005 Manila, Philippines
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Vincent Sia;
Vincent Sia
1College of Medicine,
San Beda College
, 638 Mendiola Street, San Miguel, 1005 Manila, Philippines
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Stephanie Sim;
Stephanie Sim
1College of Medicine,
San Beda College
, 638 Mendiola Street, San Miguel, 1005 Manila, Philippines
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Fernandino Jose Fontanilla;
Fernandino Jose Fontanilla
1College of Medicine,
San Beda College
, 638 Mendiola Street, San Miguel, 1005 Manila, Philippines
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Michael Ples
Michael Ples
2Biology Department, College of Science,
De La Salle University
, 2401 Taft Avenue, 1004 Manila, Philippines
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a)
Corresponding author: [email protected]
AIP Conf. Proc. 1744, 020043 (2016)
Citation
Pacifico Eric Calderon, Chrizarah San Juan, Mary Grace San Pedro, Ariane Marie Reyes, Patrick Jerome Salom, Arnel Rheuim Sanchez, Hazel Sandigan, Heshvey Joy Sangayab, Maria Cristine Joy Saure, Mar Henrick Savilla, Desmond Santos, Jamee Lou Santos, Vincent Sia, Stephanie Sim, Fernandino Jose Fontanilla, Michael Ples; Protective influence of Carica papaya L. aqueous leaf extract against hyperuricemia and acute renal injury in a murine model. AIP Conf. Proc. 14 June 2016; 1744 (1): 020043. https://doi.org/10.1063/1.4953517
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