Hearing requires precise detection and coding of acoustic signals by the inner ear and equally precise communication of the information through the auditory brainstem. A membrane based motor in the outer hair cell lateral wall contributes to the transformation of sound into a precise neural code. Structural, molecular and energetic similarities between the outer hair cell and auditory brainstem neurons suggest that a similar membrane based motor may contribute to signal processing in the auditory CNS. Cooperative activation of voltage gated ion channels enhances neuronal temporal processing and increases the upper frequency limit for phase locking. We explore the possibility that membrane mechanics contribute to ion channel cooperativity as a consequence of the nearly instantaneous speed of electromechanical signaling and the fact that membrane composition and mechanics modulate ion channel function.
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Research Article| December 31 2015
The neuromechanics of hearing
Mussie K. Araya;
AIP Conf. Proc. 1703, 030008 (2015)
Mussie K. Araya, William E. Brownell; The neuromechanics of hearing. AIP Conf. Proc. 31 December 2015; 1703 (1): 030008. https://doi.org/10.1063/1.4939323
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