Active hair-bundle motility endows hair cells with several traits that augment auditory stimuli. The activity of a hair bundle might be controlled by adjusting its mechanical properties. Indeed, the mechanical properties of bundles vary between different organisms and along the tonotopic axis of a single auditory organ. Motivated by these biological differences and a dynamical model of hair-bundle motility, we explore how adjusting the mass, drag, stiffness, and offset force applied to a bundle control its dynamics and response to external perturbations. Utilizing a mechanical-load clamp, we systematically mapped the two-dimensional state diagram of a hair bundle. The clamp system used a real-time processor to tightly control each of the virtual mechanical elements. Increasing the stiffness of a hair bundle advances its operating point from a spontaneously oscillating regime into a quiescent regime. As predicted by a dynamical model of hair-bundle mechanics, this boundary constitutes a Hopf bifurcation.
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31 December 2015
MECHANICS OF HEARING: PROTEIN TO PERCEPTION: Proceedings of the 12th International Workshop on the Mechanics of Hearing
23–29 June 2014
Cape Sounio, Greece
Research Article|
December 31 2015
Characterization of active hair-bundle motility by a mechanical-load clamp
Joshua D. Salvi;
Joshua D. Salvi
*Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience,
The Rockefeller University
, New York, New York, USA
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Dáibhid Ó Maoiléidigh;
Dáibhid Ó Maoiléidigh
*Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience,
The Rockefeller University
, New York, New York, USA
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Brian A. Fabella;
Brian A. Fabella
*Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience,
The Rockefeller University
, New York, New York, USA
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Mélanie Tobin;
Mélanie Tobin
†Laboratoire Physico-Chimie Curie,
Centre National de la Recherche Scientifique
, Institut Curie, Paris, France
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A. J. Hudspeth
A. J. Hudspeth
*Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience,
The Rockefeller University
, New York, New York, USA
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AIP Conf. Proc. 1703, 030005 (2015)
Citation
Joshua D. Salvi, Dáibhid Ó Maoiléidigh, Brian A. Fabella, Mélanie Tobin, A. J. Hudspeth; Characterization of active hair-bundle motility by a mechanical-load clamp. AIP Conf. Proc. 31 December 2015; 1703 (1): 030005. https://doi.org/10.1063/1.4939320
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