Antibacterial activities of Syzygium polyanthum wight leaves

Public health is one of the main problems for the people of Indonesia. One of the causes of health problems is pathogenic bacteria from the environment that easily enter the body and multiply to produce various diseases and infections. Plants extracts are one of the most important natural resources and alternative in the treatment effort as well as improving public health. This research was conducted to determine the antibacterial activities of methanol extract from Syzygium polyanthum Wight leaves as well as its fractions against bacteria Gram-positive Staphylococcus aureus and bacteria Gram-negative Eschericia coli. Ampicillin as positive control showed antibacterial activities against S. aureus and E. coli with IC₅₀ value of 37.82 µg/mL and 10.28 µg/mL, respectively. Methanol extract showed antibacterial activities against S. aureus and E. coli with IC₅₀ value of 23.16 µg/mL and 35.01 µg/mL, respectively. The n-hexane fraction had the highest antibacterial activity against S. aureus and E. coli with IC₅₀ value of 49.25 µg/mL and 27.54 µg/mL, respectively, compared with aqueous and ethyl acetate fractions. The results demonstrated of methanol extract of S. polyanthum Wight leaves and its fractions as antibacterial sources.