Age Dimension Homeostasis of Physiological Systems, a Slow Dynamics Model in Biology

Throughout the life span, complex physiological systems are regulated by specific age related mechanisms, thus maintaining the age axis homeostasis. Our efforts for understanding the underlying mechanisms began about a decade ago, successfully discovering the very fist such a mechanism, we called the ASE/AIE‐mediated age‐related regulatory mechanism of gene expression. This mechanism can explain the major feature of the age‐related increase profile of blood coagulation activity. Global analyses of the mouse liver genes and proteins revealed heir highly dynamic and complex age‐related regulation, suggesting the existence of several major phases over the life span. These studies facilitate a systematic investigation into the regulatory mechanisms of age‐axis homeostasis, a slow dynamics system of the complex biological systems.