Throughout the life span, complex physiological systems are regulated by specific age related mechanisms, thus maintaining the age axis homeostasis. Our efforts for understanding the underlying mechanisms began about a decade ago, successfully discovering the very fist such a mechanism, we called the ASE/AIE‐mediated age‐related regulatory mechanism of gene expression. This mechanism can explain the major feature of the age‐related increase profile of blood coagulation activity. Global analyses of the mouse liver genes and proteins revealed heir highly dynamic and complex age‐related regulation, suggesting the existence of several major phases over the life span. These studies facilitate a systematic investigation into the regulatory mechanisms of age‐axis homeostasis, a slow dynamics system of the complex biological systems.
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5 May 2006
FLOW DYNAMICS: The Second International Conference on Flow Dynamics
16-18 November 2005
Sendai (Japan)
Research Article|
May 05 2006
Age Dimension Homeostasis of Physiological Systems, a Slow Dynamics Model in Biology
K. Kurachi;
K. Kurachi
Age Dimension Research Center, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaragi 305‐8566, Japan
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M. Yasui;
M. Yasui
Age Dimension Research Center, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaragi 305‐8566, Japan
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T. Isobe;
T. Isobe
Age Dimension Research Center, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaragi 305‐8566, Japan
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E. Suenaga;
E. Suenaga
Age Dimension Research Center, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaragi 305‐8566, Japan
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S. Kurachi
S. Kurachi
Age Dimension Research Center, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaragi 305‐8566, Japan
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K. Kurachi
M. Yasui
T. Isobe
E. Suenaga
S. Kurachi
Age Dimension Research Center, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaragi 305‐8566, Japan
AIP Conf. Proc. 832, 498–503 (2006)
Citation
K. Kurachi, M. Yasui, T. Isobe, E. Suenaga, S. Kurachi; Age Dimension Homeostasis of Physiological Systems, a Slow Dynamics Model in Biology. AIP Conf. Proc. 5 May 2006; 832 (1): 498–503. https://doi.org/10.1063/1.2204547
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