We present a novel technique for synchronizing diagnostic ultrasound imaging and High‐Intensity Focused Ultrasound (HIFU) therapy systems for real‐time image‐guided therapy that does not require any modification of a commercial imaging system. HIFU therapy with a duty cycle of 83% could be performed simultaneously with B‐mode imaging by combining 5 image frames to remove HIFU interference in the entire field of view, with an overall frame rate of 11 frames/s. In vivo experiments in rabbit thigh muscle showed that the volume of HIFU‐treated lesions increased by 342% (p<0.01) when the duty cycle was increased from 50% to 95% for the same HIFU treatment times. The HIFU treatment time required at 90% duty cycle was 64% less (p<0.05) than that required at a 50% duty cycle to create lesions of the same volume.
Real‐Time Ultrasound‐Guided High‐Intensity Focused Ultrasound Therapy with Enhanced Visualization and Reduced Treatment Time
Siddhartha Sikdar, Vesna Zderic, Ravi Managuli, Shahram Vaezy, Yongmin Kim; Real‐Time Ultrasound‐Guided High‐Intensity Focused Ultrasound Therapy with Enhanced Visualization and Reduced Treatment Time. AIP Conf. Proc. 28 March 2005; 754 (1): 47–51. https://doi.org/10.1063/1.1901597
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