Astronauts experience severe/invasive disorders caused by space environments. These include hematological and cardiac abnormalities, bone and muscle losses, immunodeficiency, neurological disorders and cancer. Exploiting the extraordinary plasticity of hematopoietic stem cells (HSCs), which differentiate not only to all types of blood cells, but also to various tissues, including muscle, bone, skin, liver, and neuronal cells, we advanced a hypothesis that some of the space‐caused disorders might be amenable to hematopoietic stem cell therapy (HSCT) so as to maintain astronauts’ homeostasis. If this were achievable, the HSCT could promote human exploration of deep space. Using mouse models of human anemia (β‐thalassemia) and spaceflight (hindlimb suspension unloading system), we have obtained feasibility results of HSCT for space anemia, muscle loss, and immunodeficiency. For example, the β‐thalassemic mice were successfully transplanted with isologous HSCs, resulting in chimerism of hemoglobin species and alleviation of the hemoglobinopathy. In the case of HSCT for muscle loss, β‐galactosidase‐marked HSCs, which were prepared from β‐galactosidase‐transgenic mice, were detected by the X‐gal wholemount staining procedure in the hindlimbs of unloaded mice following transplantation. Histochemical and physical analyses indicated structural contribution of HSCs to the muscle. To investigate HSCT for immunodeficiency, β‐galactosidase‐transformed Escherichia coli was used as the reporter bacteria, and infected to control and the hindlimb suspended mice. Results of the X‐gal stained tissues indicated that the HSCT could help eliminate the E. coli infection. In an effort to facilitate the HSCT in space, growth of HSCs has been optimized in the NASA Rotating Wall Vessel (RWV) culture systems, including Hydrodynamic Focusing Bioreactor (HFB).
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4 February 2004
SPACE TECHNOLOGY AND APPLICATIONS INTERNAT.FORUM-STAIF 2004: Conf.on Thermophys.in Microgravity; Commercial/Civil Next Gen.Space Transp.; 21st Symp.Space Nuclear Power & Propulsion; Human Space Explor.; Space Colonization; New Frontiers & Future Concepts
8-11 February 2004
Albuquerque, New Mexico (USA)
Research Article|
February 04 2004
The Hematopoietic Stem Cell Therapy for Exploration of Deep Space
Seigo Ohi;
Seigo Ohi
1Howard University and Hospital, Washington, DC
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Allana‐Nicole Roach;
Allana‐Nicole Roach
1Howard University and Hospital, Washington, DC
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Shweta Ramsahai;
Shweta Ramsahai
1Howard University and Hospital, Washington, DC
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Bak C. Kim;
Bak C. Kim
1Howard University and Hospital, Washington, DC
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Wendy Fitzgerald;
Wendy Fitzgerald
2NASA/NIH Center for Three‐Dimensional Tissue Culture, Wyle Laboratories, Bethesda, MD
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Danny A. Riley;
Danny A. Riley
3Medical Col. of Wisconsin, Milwaukee, WI
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Steven R. Gonda
Steven R. Gonda
4NASA Johnson Space Center, Houston, TX
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Seigo Ohi
1
Allana‐Nicole Roach
1
Shweta Ramsahai
1
Bak C. Kim
1
Wendy Fitzgerald
2
Danny A. Riley
3
Steven R. Gonda
4
1Howard University and Hospital, Washington, DC
2NASA/NIH Center for Three‐Dimensional Tissue Culture, Wyle Laboratories, Bethesda, MD
3Medical Col. of Wisconsin, Milwaukee, WI
4NASA Johnson Space Center, Houston, TX
AIP Conf. Proc. 699, 938–950 (2004)
Citation
Seigo Ohi, Allana‐Nicole Roach, Shweta Ramsahai, Bak C. Kim, Wendy Fitzgerald, Danny A. Riley, Steven R. Gonda; The Hematopoietic Stem Cell Therapy for Exploration of Deep Space. AIP Conf. Proc. 4 February 2004; 699 (1): 938–950. https://doi.org/10.1063/1.1649659
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