Production of $17F,$ $15O$ and other radioisotopes for PET using a 3 MV electrostatic tandem accelerator

Target systems for the production of positron emitting radioisotopes used for medical research with positron emission tomography (PET) are under development for a 3 MV electrostatic tandem accelerator (NEC 9SDH-2). This machine is intended primarily for the continuous production of short lived tracers labeled with $15O$ $(t1/2=122 s)$ or $17F$ $(t1/2=65 s)$ for determining regional cerebral blood flow in humans. Simple gas, liquid, and solid target systems are presented for the production of $[15O]H2O$ (yield at saturation 13 mCi/μA), $[17F]F2 (22 mCi/μA),$ $[17F]$ fluoride (aq.) (12 mCi/μA), $[18F]$fluoride (aq.) (21 mCi/μA), $[13N]$ in graphite (25 mCi/μA), and $[11C]CO2 (2.3 mCi/μA).$ Current limitations on single window targets for each production are discussed.