A concept of “Space Factory” on the International Space Station Alpha (ISSA) is described. By following the four great observatories that purposefully took advantage of the Space Transportation System (STS), the next generation of great observatories is considered. These new astronomical projects require a very large optical telescope whose diameter is of the order of 10 m. Space telescope of this size will require careful assembly and tuning by astronauts on orbit before deployment. Once built, it could visualize the universe to the earliest galaxies, and could explore the earth-like planet in other star-system. The “Space Factory” would permit other large-scale observatories for construction in space. A step-by-step advancement of the “Space Factory” is conceived by including four or five frontier astrophysics programs. Less demanding experiments would precede the construction project of the most demanding optical telescope. A study in Japan to observe the highest energy cosmic rays from space is synchronized with those being carried out by the OWL team in the USA and the AIRWATCH team in Italy. The Japanese efforts are coordinated in a larger program study of the Space SUBARU, which envisages a plan of orbital construction, fine-tuning and eventual deployment of large scale astrophysical instruments into the desired free-flying orbit. A space observatory of the highest energy cosmic rays can be maximized by a cluster of 6 or 7 units of the wide-angle OWL telescopes, each having a field-of-view (FOV) of ∼60°. The ultimate viewing area could be up to 6,000 km×6,000 km, the entire horizon for a 1000 km orbit. Within this large detection area about 105 cosmic hadronic events at above 1020eV would be observed in a year. It also makes possible to observe the highest energy neutrinos from the known source mechanisms; including cosmic photo-production. Neutrino events from Topological Defects, Gamma Ray Burst fireballs and Blazers are observable as frequently as ∼100 events per year above 1020eV, if any of these hypothetical sources is real.

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