Functional polymer composites have emerged as promising materials for a wide range of biomedical applications due to their tunable properties and biocompatibility. This review provides a comprehensive overview of the state-of-the-art advancements and future perspectives in the field of functional polymer composites for biomedical applications. The review begins by discussing the unique properties of polymer composites that make them suitable for biomedical use, including their mechanical strength, flexibility, and tailorable surface properties. Various functionalization techniques, such as surface modification, incorporation of bioactive molecules, and nanoparticle doping, are highlighted for imparting specific functionalities to the polymer matrix, including antibacterial, antifouling, and bioactive properties. Furthermore, the review delves into specific biomedical applications where functional polymer composites have shown promise, including tissue engineering, drug delivery systems, biosensors, and medical implants. For each application, key challenges and recent advancements are discussed, providing insights into current research trends and future directions. Moreover, the review examines the biocompatibility and cytotoxicity aspects of functional polymer composites, emphasizing the importance of rigorous biocompatibility testing to ensure safe and effective use in biomedical settings. Additionally, the review discusses emerging trends and future perspectives in the field, such as the development of smart and stimuli-responsive polymer composites for targeted drug delivery and tissue regeneration. Moreover, the integration of advanced fabrication techniques, such as 3D printing and electrospinning, is explored for the precise control of composite architecture and properties. Overall, this review provides a comprehensive understanding of the current state-of-the-art in functional polymer composites for biomedical applications, while also outlining future research directions to address current challenges and meet the evolving needs of the biomedical field.

1.
M.
Ramesh
,
T. S.
Manickam
,
F. S.
Arockiasamy
,
B.
Ponnusamy
,
S.
Senthilraj
,
D.
Chellamuthu
, and
P.
Palanisamy
, in
The International Conference on Processing and Performance of Materials (ICPPM 2023)
,
MDPI
,
Basel Switzerland
, p.
17
(
2024
).
2.
S.
Nain
,
S.
Chakraborty
,
S. R.
Barman
,
P.
Gavit
,
S.
Indrakumar
,
A.
Agarwal
,
Z.-H.
Lin
, and
K.
Chatterjee
,
Biomaterials
, vol.
122528
, (
2024
).
3.
V.
Gavande
,
S.
Nagappan
,
B.
Seo
, and
W.-K.
Lee
,
Int. J. Biol. Macromol.
, vol.
262
, pp.
130
135
(
2024
).
4.
C.-H.
Kim
,
S.-Y.
Lee
,
K. Y.
Rhee
, and
S.-J.
Park
,
Adv. Compos. Hybrid Mater.
, vol.
7
, p.
55
(
2024
).
5.
N.
Shahid
,
A.
Erum
,
S.
Hanif
,
N. S.
Malik
,
U. R.
Tulain
, and
M. A.
Syed
,
Curr. Pharm. Des.
, vol.
30
, p.
48
(
2024
).
6.
S.
Liu
,
J.-M.
Yu
,
Y.-C.
Gan
,
X.-Z.
Qiu
,
Z.-C.
Gao
,
H.
Wang
,
S.-X.
Chen
,
Y.
Xiong
,
G.-H.
Liu
,
S.-E.
Lin
,
A.
McCarthy
,
J. V.
John
,
D.-X.
Wei
,
H.-H.
Hou
,
S.-X.
Chen
, and
U. Dai-Xu
Wei
,
Military Med. Res.
, vol.
10
, no.
1
, p.
10
(
2023
).
7.
Z. U.
Arif
,
M. Y.
Khalid
,
R.
Noroozi
,
A.
Sadeghianmaryan
,
M.
Jalalvand
, and
M.
Hossain
,
Int. J. Biol. Macromol.
, vol.
218
, p.
930
(
2022
).
8.
M.
Samie
,
A. F.
Khan
,
S. U.
Rahman
,
H.
Iqbal
,
M. A.
Yameen
,
A. A.
Chaudhry
,
H. A.
Galeb
,
N. R.
Halcovitch
, and
J. G.
Hardy
,
Int. J. Biol. Macromol.
, vol.
229
, p.
561
(
2023
).
9.
K. C.
Wong
,
Orthop. Res. Rev.
, vol.
8
, p.
57
(
2016
).
10.
M.
Janmohammadi
,
Z.
Nazemi
,
A. O. M.
Salehi
,
A.
Seyfoori
,
J. V.
John
,
M. S.
Nourbakhsh
, and
M.
Akbari
,
Bioact. Mater.
, vol.
20
, p.
137
(
2023
).
11.
S.
Das
,
B.
Ghosh
, and
K.
Sarkar
,
Sensors Int.
, vol.
3
, p.
100135
(
2022
).
12.
U.
D'Amora
,
S.
Dacrory
,
M. S.
Hasanin
,
A.
Longo
,
A.
Soriente
,
S.
Kamel
,
M. G.
Raucci
,
L.
Ambrosio
, and
S.
Scialla
,
Pharmaceutics
, vol.
15
, p.
338
(
2023
).
13.
V.
Harish
,
D.
Tewari
,
M.
Gaur
,
A. B.
Yadav
,
S.
Swaroop
,
M.
Bechelany
, and
A.
Barhoum
,
Nanomaterials
, vol.
12
, p.
457
(
2022
).
14.
M.
Kus-liśkiewicz
,
P.
Fickers
, and
I.
Ben Tahar
,
Int. J. Mol. Sci.
, vol.
22
, p.
10952
(
2021
).
15.
S. N.
Wuersching
,
C.
Högg
,
L.
Kohl
,
F. X.
Reichl
,
R.
Hickel
, and
M.
Kollmuss
,
Dent. Mater.
, vol.
39
, p.
293
(
2023
).
16.
M.
Ramesh
,
T. S.
Manickam
,
F. S.
Arockiasamy
,
B.
Ponnusamy
,
R.
Sivakumar
,
P.
Sivakumar
, and
P.
Kandasamy
, in
The International Conference on Processing and Performance of Materials (ICPPM 2023)
,
MDPI
,
Basel Switzerland
, p.
24
(
2024
).
17.
A. F.
Sahayaraj
,
M. T.
Selvan
,
M.
Ramesh
,
J.
Maniraj
,
I.
Jenish
, and
K. J.
Nagarajan
,
Biomass Convers. Biorefin.
, vol.
1
, (
2024
).
18.
C.
Jiao
,
D.
Xie
,
Z.
He
,
H.
Liang
,
L.
Shen
,
Y.
Yang
,
Z.
Tian
,
G.
Wu
, and
C.
Wang
,
Mater. Des.
, vol.
217
, p.
110610
(
2022
).
19.
S.
Beg
,
W. H.
Almalki
,
A.
Malik
,
M.
Farhan
,
M.
Aatif
,
Z.
Rahman
,
N. K.
Alruwaili
,
M.
Alrobaian
,
M.
Tarique
, and
M.
Rahman
,
Drug Discovery Today
, vol.
25
, p.
1668
(
2020
).
20.
H.
Ryu
,
M. H.
Seo
, and
J. A.
Rogers
,
Adv. Healthcare Mater.
, vol.
10
, p.
2002236
(
2021
).
21.
G.
Wei
,
M.
Tan
,
S.
Attarilar
,
J.
Li
,
V. V.
Uglov
,
B.
Wang
,
J.
Liu
,
L.
Lu
, and
L.
Wang
,
J. Mater. Res. Technol.
, vol.
24
, p.
5896
(
2023
).
22.
Z.
Xiao
,
S.
Zhao
,
X.
Zhang
,
G.
Wei
, and
Z.
Su
,
Macromol. Mater. Eng.
, vol.
307
, p.
2200385
(
2022
).
23.
M.
Mbogori
,
A.
Vaish
,
R.
Vaishya
,
A.
Haleem
, and
M.
Javaid
,
J. Orthop. Rep.
, vol.
1
, p.
3
(
2022
).
24.
R. M.
Zaki
,
C.
Strutynski
,
S.
Kaser
,
D.
Bernard
,
G.
Hauss
,
M.
Faessel
,
J.
Sabatier
,
L.
Canioni
,
Y.
Messaddeq
,
S.
Danto
, and
T.
Cardinal
,
Mater. Des.
, vol.
194
, p.
108957
(
2020
).
25.
F.
Sahayaraj
,
M. Tamil
Selvan
,
M. Sasi
Kumar
,
S.
Sathish
,
S.
Gokulkumar
,
I.
Jenish
, and
M.
Makeshkumar
,
Polym.-Plast. Technol. Mater.
, vol.
00
, p.
1
(
2024
).
26.
M.
Ramesh
,
T.
Vinitha
, and
M. Tamil
Selvan
,
Biocomposites Ind. Appl.
, p.
149
(
2024
).
27.
T. J.
Theka
,
B. R. J.
Thamaga
,
Z. P.
Tshabalala
,
R. G.
Motsoeneng
,
H. C.
Swart
, and
D. E.
Motaung
,
Appl. Surf. Sci.
, vol.
644
, p.
158789
(
2024
).
28.
P.
Arul
,
S. T.
Huang
,
N. S. K.
Gowthaman
,
M.
Govindasamy
, and
N.
Jeromiyas
,
Microchim. Acta
, vol.
187
, p.
1
(
2020
).
29.
M.
Ramesh
,
M. T.
Selvan
, and
A. F.
Sahayaraj
, in
Epoxy-Based Biocomposites
,
CRC Press
,
Boca Raton
, pp.
101
120
(
2023
).
30.
Aimar
,
A.
Palermo
, and
B.
Innocenti
,
J. Healthcare Eng.
, vol.
2019
, (
2019
).
31.
M.
Ramesh
,
T.
Vinitha
, and
M. Tamil
Selvan
, in
Tribological Properties, Performance and Applications of Biocomposites
,
Wiley
, pp.
1
18
(
2024
).
32.
J.
Iyyadurai
,
F. S.
Arockiasamy
,
T. S.
Manickam
,
I.
Suyambulingam
,
S.
Siengchin
,
M.
Appadurai
, and
E. F. I.
Raj
,
Silicon
, vol.
1
, (
2023
).
33.
M.
Ramesh
,
K.
Niranjana
, and
M. Tamil
Selvan
, in
Tribological Properties, Performance and Applications of Biocomposites
,
Wiley
, pp.
219
246
(
2024
).
34.
V.
Mani
,
K.
Krishnaswamy
,
F. S.
Arockiasamy
, and
T. S.
Manickam
,
Int. Polym. Process.
, (
2023
).
35.
A. F.
Sahayaraj
,
M. T.
Selvan
,
I.
Jenish
, and
M.
Ramesh
,
Biomass Convers. Biorefin.
, vol.
1
, (
2023
).
36.
M.
Ramesh
,
C.
Deepa
,
L.
Rajeshkumar
,
C.
Deepa
, and
A.
Ahmad
,
J. Polym. Res.
, vol.
19
, p.
13776
(
2022
).
37.
A. D.
Sontakke
,
S.
Tiwari
, and
M. K.
Purkait
,
FlatChem
, vol.
38
, p.
100484
(
2023
).
38.
P.
Iravani
,
S.
Iravani
, and
R. S.
Varma
,
Micromachines
, vol.
13
, p.
1383
(
2022
).
39.
A. F.
Sahayaraj
,
I.
Jenish
,
M.
Tamilselvan
,
M.
Muthukrishnan
, and
B. A.
Kumar
,
Int. Polym. Process.
, vol.
37
, p.
581
(
2022
).
40.
M.
Ramesh
,
M. T.
Selvan
, and
K.
Niranjana
,
Polym. Compos.
, vol.
43
, p.
6453
(
2022
).
41.
N. A.
Patil
,
J.
Njuguna
, and
B.
Kandasubramanian
,
Eur. Polym. J.
, vol.
125
, p.
109529
(
2020
).
42.
M.
Ramesh
,
C.
Deepa
,
L.
Rajeshkumar
,
M. Tamil
Selvan
, and
D.
Balaji
,
Polym. Compos.
, vol.
42
, p.
4308
(
2021
).
43.
Lerebours
,
P.
Vigneron
,
S.
Bouvier
,
A.
Rassineux
,
M.
Bigerelle
, and
C.
Egles
,
Bioprinting
, vol.
16
, p.
e00054
(
2019
).
44.
T.
Manickam
,
J.
Iyyadurai
,
M.
Jaganathan
,
A.
Babuchellam
,
M.
Mayakrishnan
, and
F. S.
Arockiasamy
,
Int. Polym. Process.
, (
2022
).
45.
J.
Iyyadurai
,
F. S.
Arockiasamy
,
T.
Manickam
,
S.
Rajaram
,
I.
Suyambulingam
, and
S.
Siengchin
,
J. Inorg. Organomet. Polym. Mater.
, vol.
1
, (
2023
).
46.
Y.
Pu
,
X.
Fan
,
Z.
Zhang
,
Z.
Guo
,
Q.
Pan
,
W.
Gao
,
K.
Luo
, and
B.
He
,
J. Controlled Release
, vol.
354
, p.
1
(
2023
).
47.
N.
Liu
,
X.
Ye
,
B.
Yao
,
M.
Zhao
,
P.
Wu
,
G.
Liu
,
D.
Zhuang
,
H.
Jiang
,
X.
Chen
,
Y.
He
,
S.
Huang
, and
P.
Zhu
,
Bioact. Mater.
, vol.
6
, p.
1388
(
2021
).
48.
M.
Ramesh
,
M. Tamil
Selvan
, and
K.
Niranjana
,
(Springer, Singapore
,
2022
), pp.
257
277
(
2024
).
49.
M.
Ramesh
,
C.
Deepa
,
M. Tamil
Selvan
,
L.
Rajeshkumar
,
D.
Balaji
, and
V.
Bhuvaneswari
,
Mater. Today Proc.
, vol.
46
, p.
3367
(
2020
).
50.
S. M.
Mousavi
,
S. A.
Hashemi
,
M. Y.
Kalashgrani
,
N.
Omidifar
,
S.
Bahrani
,
N. V.
Rao
,
A.
Babapoor
,
A.
Gholami
, and
W. H.
Chiang
,
Polymers
, vol.
14
, p.
617
(
2022
).
51.
M.
Ramesh
,
L.
Rajeshkumar
,
C.
Deepa
,
M. Tamil
Selvan
, and
D.
Balaji
,
Polym. Compos.
, vol.
42
, p.
4308
(
2021
).
52.
M. M.
Germaini
,
S.
Belhabib
,
S.
Guessasma
,
R.
Deterre
,
P.
Corre
, and
P.
Weiss
,
Prog. Mater. Sci.
, vol.
130
, p.
100963
(
2022
).
53.
M.
Ramesh
,
C.
Deepa
,
M. Tamil
Selvan
, and
K. H.
Reddy
,
J. Nat. Fibers
, vol.
19
, p.
931
(
2022
).
54.
M. T.
Selvan
,
I.
Jenish
,
M.
Ramesh
, and
A. F.
Sahayaraj
,
Biomass Convers. Biorefin.
, (
2023
).
55.
B. S.
Dakshayini
,
K. R.
Reddy
,
A.
Mishra
,
N. P.
Shetti
,
S. J.
Malode
,
S.
Basu
,
S.
Naveen
, and
A. V.
Raghu
,
Microchem. J.
, vol.
147
, p.
7
(
2019
).
56.
X.
Fu
,
B.
Ding
, and
D.
D'Alessandro
,
Coord. Chem. Rev.
, vol.
475
, (
2023
).
57.
W.
Jamróz
,
J.
Szafraniec
,
M.
Kurek
, and
R.
Jachowicz
,
Pharm. Res.
, vol.
35
, p.
1
(
2018
).
58.
S.
Kolluru
,
A.
Thakur
,
D.
Tamakuwala
,
V. V.
Kumar
,
S.
Ramakrishna
, and
S.
Chandran
,
Polym. Bull.
, (
2024
).
59.
M.
Varma
,
S.
Chandran
,
V. Vijay
Kumar
,
I.
Suyambulingam
, and
S.
Siengchin
,
Polym. Compos.
, (
2024
).
60.
S. S. A. P. R G
,
G.
Bajaj
,
A. E.
John
,
S.
Chandran
,
V. V.
Kumar
, and
S. Ramakr
Ishna
,
J. Mater. Sci. Mater. Med.
, vol.
34
, p.
62
(
2023
).
61.
M.
Vijayan
,
V.
Selladurai
, and
V. V.
Kumar
,
Silicon
, vol.
15
, p.
4845
(
2023
).
62.
V. Vijay
Kumar
,
S.
Ramakrishna
,
S.
Rajendran
, and
S.
Surendran
,
Mater. Today Proc.
, vol.
67
, p.
1
(
2022
).
63.
H.
Musarurwa
and
N. T.
Tavengwa
,
Carbohydr. Polym.
, vol.
298
, p.
120083
(
2022
).
64.
R.
Nasseri
,
C. P.
Deutschman
,
L.
Han
,
M. A.
Pope
, and
K. C.
Tam
,
Mater. Today Adv.
, vol.
5
, p.
100055
(
2020
).
65.
D. A. K. M.
Ramesh
,
M. Tamil
Selvan
,
P.
Hariprasad
, in
Advanced Applications of Micro and Nano Clay II: Synthetic Polymer Composites
, pp.
203
232
(
2022
).
This content is only available via PDF.
You do not currently have access to this content.