N-heterocyclic carbenes produced from benzimidazoles are complexed with platinum (II) (Z1-Z4) and were effectively synthesized in a single pot using [PtCl2] salts of 1,3-disubstituted benzimidazolium. The FTIR and 1H, and 13C NMR data were used to characterize the prepared end complexes. The synthesized new platinum(II) N-heterocyclic carbene complexes were biologically evaluated for in vitro antibacterial activity estimated against some types of bacteria strains S. aureus. and E. coli.

1.
Gaonkar
S.L. N. S.
,
ChemMedChem.
,
2021
,
6
,
1360
1390
.
2.
Kai-Wa
I.
,
Sze-Wing
N.
,
Chi-Fung
Y.
,
Chun-Yuen
W.
Chemistry - A European Journal
,
2020
,
24
,
2302
2389
.
3.
Moulali
V.
,
Arruri
S.
,
Yamane
M.
,
Shohei
S.
,
Ozaki
K.
,
Kavitha
V.
,
Kalaivanan
S.
,
Kyohei
H.
,
Osamu
T.
,
Ganesan
P.
Organometallics
,
2020
,
39
,
2202
2206
4.
Nguyen
V.H.
,
T.T.
Dang
,
H.H.
Nguyen
,
H.V.
Huynh
,
Platinum(II) 1,2,4-Triazolin-5-ylidene Complexes: Stereo electronic Influences on Their Catalytic Activity in Hydroelementation Reactions
,
Organometallics
39
(
2020
)
2309
2319
.
5.
Maliszewski
B.P.
,
N.V.
Tzouras
,
S.G.
Guillet
,
M.
Saab
,
M.
Beliš
,
K.V.
Hecke
,
F.
Nahra
,
S.P.
Nolan
,
A general protocol for the synthesis of PtNHC (NHC=N-heterocyclic carbene) hydrosilylation catalysts
,
Dalton Trans.
49
(
2020
)
14673
14679
.
6.
Nguyen
C.T.T.
,
V.T.
Pham
,
H.V.
Huynh
,
Mixed Arylolefin/NHC Complexes of Platinum(II): Syntheses, Characterizations, and In Vitro Cytotoxicities
,
Organometallics
39
(
2020
)
3505
3513
.
7.
K.
Li
,
T.
Zou
,
Y.
Chen
,
X.
Guan
,
C.M.
Che
,
Pincer-Type Platinum(II) Complexes Containing N-Heterocyclic Carbene (NHC) Ligand: Structures, Photophysical and Anion-Binding Properties, and Anticancer Activities
,
Chem. Eur. J.
21
(
2015
)
7441
7453
.
8.
T.C.
Johnstone
,
K.
Suntharalingam
,
S.J.
Lippard
,
The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs
,
Chem. Rev.
116
(
2016
)
3436
3486
.
9.
S.
Rottenberg
,
C.
Disler
,
P.
Perego
,
The rediscovery of platinum-based cancer therapy
,
Nat. Rev. Cancer
21
(
2021
)
37
50
.
10.
Y.
Ai
,
Y.
Li
,
H.
Ma
,
C.Y.
Su
,
V.W.W.
Yam
.
Cyclometalated Platinum(II) Complexes of 1,3-Bis(1-N-butylpyrazol-3-yl)benzenes: Synthesis, Characterization, Electrochemical, Photophysical, and Gelation Behavior Studies
.
Inorg. Chem.
55
(
2016
)
11920
11929
.
11.
M.L.
Saha
,
X.
Yan
,
P.J.
Stang
,
Photophysical Properties of Organoplatinum(II) Compounds and Derived Self-Assembled Metallacycles and Metallacages: Fluorescence and its Applications
,
Acc. Chem. Res.
49
(
2016
)
2527
2539
.
12.
V.W.W.
Yam
,
V.K.M
Au
,
S.Y.K.
Leung
,
Light Emitting Self-Assembled Materials Based on d8 and d10 Transition Metal Complexes
,
Chem. Rev.
115
(
2015
)
7589
7728
.
13.
W.A.
Herrmann
,
N-Heterocyclic Carbenes: A New Concept in Organometallic Catalysis
,
Angew. Chem. Int.
Ed.
41
(
2002
)
1290
1309
.
14.
N.
Marion
,
S.P.
Nolan
,
Well-Defined NHeterocyclic Carbenes−Palladium(II) Precatalysts for Cross-Coupling Reactions
,
Acc. Chem. Res.
41
(
2008
)
1440
1449
.
15.
M.N.
Hopkinson
,
C.
Richter
,
M.
Schedler
,
F.
Glorius
,
An overview of N-heterocyclic carbenes
,
Nature
510
(
2014
)
485
496
.
16.
T.
Strassner
,
Phosphorescent Platinum(II) Complexes with C^C* Cyclometalated NHC Ligands
,
Acc. Chem. Res.
49
(
2016
)
2680
2689
17.
Dehyaa Hussain
Mohsen
,
Ali Jabbar
Radhi
,
Dhurgham Qasim
Shaheed
, &
Hayder Kadhim
Abbas
. (
2022
).
Synthesis New Benzimidazole Derivatives as Antibacterial
.
Journal of Pharmaceutical Negative Results
,
13
(
3
),
893
898
.
18.
Romain
Per.
,
Delphine
Ha.
,
Patrick
P.
,
Pierre
de Fré.
, and
Aurélien
Bla
.
Opinion in Chemical Biology, 2020
,
43
,
30
36
.
19.
Ali Jabbar
Radhi
,
Ezzat Hussein
Zimam
,
Emad Abbas Jaffar
Al-Mulla
,
New Barbiturate Derivatives as Potent in vitro α-Glucosidase Inhibitors, Egypt. J. Chem.
,
64
, (
1
),
117
123
(
2021
).
This content is only available via PDF.
You do not currently have access to this content.