COVID-19, arriving in Indonesia in 2020, had an impact on the learning process, one of which was practicum activities. Thus, this research aimed to describe the profile of students’ practicum skills in Oxidation-Reduction Reactions using E-Worksheet Based on Chemicals at Home. This research uses the observation method. The research was conducted on grade students in Budi Mulia Dua Senior High School, Yogyakarta, Indonesia, at the end of the first semester of the academic year 2021/2022. The data was collected using an observation sheet, which was developed based on the practicum skill dimension consisting of skills in using tools, manipulating materials, interpreting, classifying, and communicating. The data was analyzed descriptively and quantitatively. The results showed the average percentage of students in practicum skills are using tools (80%), manipulating materials (90%), interpreting (66%), classifying (86%), and communicating (86%). Overall, students’ practicum skills were in a good category, i.e. 81.6%. The activity of practicum using E-Worksheet Based on Chemicals at Home received a good category, and students gave a positive response during the learning process. Therefore, teachers need to innovate the learning process to improve students’ practicum skills.

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