Utilizing the 4,7-diphenyl-1,10-phenanthroline reagent in the spectrophotometric method for cefadroxil determination

A visible spectroscopic method for the evaluation of cefadroxil in both its pure form and in pharmaceutical formulations. Fe⁺³ ion and cefadroxil undergo an oxidation-reduction process in the technique. Following the reaction between the released Fe⁺² and 4,7-diphenyl-1,10-phenanthroline, a red complex with a maximum absorbance at 533 nm is created. There is a 2.833 x 10⁴ L. mole-1. cm-1 molar absorptivity. Over a concentration range of (0.5-15 µg.ml⁻¹), Beer’s law is observed. A reaction pathway was proposed after extensive research and optimization of several parameters that affect the growth and stability of color products. Cefadroxil in the capsule formulation was effectively identified using the suggested method. for the analysis of cefadroxil in pure form and pharmaceutical preparations was suggested.