This evaluate aimed to current study the functional and histological impact of Galangin (Gal) band with gold nanoparticles (AuNPs) drug delivery on the liver cell of male albino mice(mus musculus) injected by CCl4. The characterization was carried out using transmission electron microscopy (TEM) and Fourier Transform Infrared (FT-IR). Forty-two animals were used distributed into seven groups and treated extended for two weeks, control group (G1) animals not treated with any compounds, G2 mice were give intraperitoneal (i.p) with CCl4 once a week for 14 days in addition to the other experimental groups, G3 group give with one mM gold NPs, G4 and G5 animals give with Galangin at 10 and 20 mg/kg, G6 and G7 group give with gold NPs - Gal10 mg/kg and gold NPs-Gal 20mg/kg. The results of prepared AuNPs and AuNPs+Gal showed a sphere-shaped shape and size between 20-45 nanometers. Histopathological results changed in the mice liver tissue give with CCL4, and give with AuNPs+Gal significantly improved the histology. Moreover, Alanine Transaminase (ALT), Aspartate Transaminase (AST) and Lactate dehydrogenase (LDH) levels in blood serum increased significantly in the CCl4 group, where treatment with AuNPs-Gal reduced the levels to an almost normal level. This finding revealed that Galangin conjugated with gold NPs positively enhanced the injury by CCl4, providing a potentially active normal treatment after extensive suitable developments.
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